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Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors.
Zhang H, Yu P, Tomar VS, Chen X, Atherton MJ, Lu Z, Zhang HG, Li S, Ortiz A, Gui J, Leu NA, Yan F, Blanco A, Meyer-Ficca ML, Meyer RG, Beiting DP, Li J, Nunez-Cruz S, O'Connor RS, Johnson LR, Minn AJ, George SS, Koumenis C, Diehl JA, Milone MC, Zheng H, Fuchs SY. Zhang H, et al. Among authors: milone mc. Nat Cancer. 2022 Jul;3(7):808-820. doi: 10.1038/s43018-022-00383-0. Epub 2022 May 30. Nat Cancer. 2022. PMID: 35637402 Free PMC article.
Substrate rigidity regulates human T cell activation and proliferation.
O'Connor RS, Hao X, Shen K, Bashour K, Akimova T, Hancock WW, Kam LC, Milone MC. O'Connor RS, et al. Among authors: milone mc. J Immunol. 2012 Aug 1;189(3):1330-9. doi: 10.4049/jimmunol.1102757. Epub 2012 Jun 25. J Immunol. 2012. PMID: 22732590 Free PMC article.
Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors.
Moon EK, Wang LC, Dolfi DV, Wilson CB, Ranganathan R, Sun J, Kapoor V, Scholler J, Puré E, Milone MC, June CH, Riley JL, Wherry EJ, Albelda SM. Moon EK, et al. Among authors: milone mc. Clin Cancer Res. 2014 Aug 15;20(16):4262-73. doi: 10.1158/1078-0432.CCR-13-2627. Epub 2014 Jun 11. Clin Cancer Res. 2014. PMID: 24919573 Free PMC article.
The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.
Ruella M, Kenderian SS, Shestova O, Fraietta JA, Qayyum S, Zhang Q, Maus MV, Liu X, Nunez-Cruz S, Klichinsky M, Kawalekar OU, Milone M, Lacey SF, Mato A, Schuster SJ, Kalos M, June CH, Gill S, Wasik MA. Ruella M, et al. Clin Cancer Res. 2016 Jun 1;22(11):2684-96. doi: 10.1158/1078-0432.CCR-15-1527. Epub 2016 Jan 27. Clin Cancer Res. 2016. PMID: 26819453
Improving T Cell Expansion with a Soft Touch.
Lambert LH, Goebrecht GK, De Leo SE, O'Connor RS, Nunez-Cruz S, Li TD, Yuan J, Milone MC, Kam LC. Lambert LH, et al. Among authors: milone mc. Nano Lett. 2017 Feb 8;17(2):821-826. doi: 10.1021/acs.nanolett.6b04071. Epub 2017 Jan 30. Nano Lett. 2017. PMID: 28122453 Free PMC article.
CAR T cell immunotherapy for human cancer.
June CH, O'Connor RS, Kawalekar OU, Ghassemi S, Milone MC. June CH, et al. Among authors: milone mc. Science. 2018 Mar 23;359(6382):1361-1365. doi: 10.1126/science.aar6711. Science. 2018. PMID: 29567707 Review.
115 results