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Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.
Numao S, Hasler F, Laguerre C, Srinivas H, Wack N, Jäger P, Schmid A, Osmont A, Röthlisberger P, Houguenade J, Bergsdorf C, Dawson J, Carte N, Hofmann A, Markert C, Hardaker L, Billich A, Wolf RM, Penno CA, Bollbuck B, Miltz W, Röhn TA. Numao S, et al. Among authors: miltz w. Sci Rep. 2017 Oct 19;7(1):13591. doi: 10.1038/s41598-017-13490-1. Sci Rep. 2017. PMID: 29051536 Free PMC article.
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.
Markert C, Thoma G, Srinivas H, Bollbuck B, Lüönd RM, Miltz W, Wälchli R, Wolf R, Hinrichs J, Bergsdorf C, Azzaoui K, Penno CA, Klein K, Wack N, Jäger P, Hasler F, Beerli C, Loetscher P, Dawson J, Wieczorek G, Numao S, Littlewood-Evans A, Röhn TA. Markert C, et al. Among authors: miltz w. J Med Chem. 2021 Feb 25;64(4):1889-1903. doi: 10.1021/acs.jmedchem.0c01955. Epub 2021 Feb 16. J Med Chem. 2021. PMID: 33592148
Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.
Thoma G, Markert C, Lueoend R, Miltz W, Spanka C, Bollbuck B, Wolf RM, Srinivas H, Penno CA, Kiffe M, Gajewska M, Bednarczyk D, Wieczorek G, Evans A, Beerli C, Röhn TA. Thoma G, et al. Among authors: miltz w. J Med Chem. 2023 Dec 14;66(23):16410-16425. doi: 10.1021/acs.jmedchem.3c01866. Epub 2023 Nov 28. J Med Chem. 2023. PMID: 38015154