Mistry A - Search Results

1

Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin.

Heaslet H, Shaw B, Mistry A, Miller AA. Heaslet H, et al. Among authors: mistry a. J Struct Biol. 2009 Aug;167(2):129-35. doi: 10.1016/j.jsb.2009.04.010. Epub 2009 May 3. J Struct Biol. 2009. PMID: 19416756

2

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.

Qiu X, Mistry A, Ammirati MJ, Chrunyk BA, Clark RW, Cong Y, Culp JS, Danley DE, Freeman TB, Geoghegan KF, Griffor MC, Hawrylik SJ, Hayward CM, Hensley P, Hoth LR, Karam GA, Lira ME, Lloyd DB, McGrath KM, Stutzman-Engwall KJ, Subashi AK, Subashi TA, Thompson JF, Wang IK, Zhao H, Seddon AP. Qiu X, et al. Among authors: mistry a. Nat Struct Mol Biol. 2007 Feb;14(2):106-13. doi: 10.1038/nsmb1197. Epub 2007 Jan 21. Nat Struct Mol Biol. 2007. PMID: 17237796

3

Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.

Han S, Mistry A, Chang JS, Cunningham D, Griffor M, Bonnette PC, Wang H, Chrunyk BA, Aspnes GE, Walker DP, Brosius AD, Buckbinder L. Han S, et al. Among authors: mistry a. J Biol Chem. 2009 May 8;284(19):13193-201. doi: 10.1074/jbc.M809038200. Epub 2009 Feb 25. J Biol Chem. 2009. PMID: 19244237 Free PMC article.

4

Crystal structures of cholesteryl ester transfer protein in complex with inhibitors.

Liu S, Mistry A, Reynolds JM, Lloyd DB, Griffor MC, Perry DA, Ruggeri RB, Clark RW, Qiu X. Liu S, et al. Among authors: mistry a. J Biol Chem. 2012 Oct 26;287(44):37321-9. doi: 10.1074/jbc.M112.380063. Epub 2012 Sep 7. J Biol Chem. 2012. PMID: 22961980 Free PMC article.

5

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.

Walker DP, Bi FC, Kalgutkar AS, Bauman JN, Zhao SX, Soglia JR, Aspnes GE, Kung DW, Klug-McLeod J, Zawistoski MP, McGlynn MA, Oliver R, Dunn M, Li JC, Richter DT, Cooper BA, Kath JC, Hulford CA, Autry CL, Luzzio MJ, Ung EJ, Roberts WG, Bonnette PC, Buckbinder L, Mistry A, Griffor MC, Han S, Guzman-Perez A. Walker DP, et al. Among authors: mistry a. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6071-7. doi: 10.1016/j.bmcl.2008.10.030. Epub 2008 Oct 11. Bioorg Med Chem Lett. 2008. PMID: 18951788

6

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin.

Midelfort KS, Kumar R, Han S, Karmilowicz MJ, McConnell K, Gehlhaar DK, Mistry A, Chang JS, Anderson M, Villalobos A, Minshull J, Govindarajan S, Wong JW. Midelfort KS, et al. Among authors: mistry a. Protein Eng Des Sel. 2013 Jan;26(1):25-33. doi: 10.1093/protein/gzs065. Epub 2012 Sep 25. Protein Eng Des Sel. 2013. PMID: 23012440

7

Crystal structure of the anti-fungal target N-myristoyl transferase.

Weston SA, Camble R, Colls J, Rosenbrock G, Taylor I, Egerton M, Tucker AD, Tunnicliffe A, Mistry A, Mancia F, de la Fortelle E, Irwin J, Bricogne G, Pauptit RA. Weston SA, et al. Among authors: mistry a. Nat Struct Biol. 1998 Mar;5(3):213-21. doi: 10.1038/nsb0398-213. Nat Struct Biol. 1998. PMID: 9501915

8

Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: a cause of heterogeneity in mass and complications in function.

Du P, Loulakis P, Luo C, Mistry A, Simons SP, LeMotte PK, Rajamohan F, Rafidi K, Coleman KG, Geoghegan KF, Xie Z. Du P, et al. Among authors: mistry a. Protein Expr Purif. 2005 Dec;44(2):121-9. doi: 10.1016/j.pep.2005.04.018. Protein Expr Purif. 2005. PMID: 15946859

9

Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin.

Skarzynski T, Mistry A, Wonacott A, Hutchinson SE, Kelly VA, Duncan K. Skarzynski T, et al. Among authors: mistry a. Structure. 1996 Dec 15;4(12):1465-74. doi: 10.1016/s0969-2126(96)00153-0. Structure. 1996. PMID: 8994972 Free article.

10

Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.

Walker DP, Zawistoski MP, McGlynn MA, Li JC, Kung DW, Bonnette PC, Baumann A, Buckbinder L, Houser JA, Boer J, Mistry A, Han S, Xing L, Guzman-Perez A. Walker DP, et al. Among authors: mistry a. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3253-8. doi: 10.1016/j.bmcl.2009.04.093. Epub 2009 Apr 24. Bioorg Med Chem Lett. 2009. PMID: 19428251

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