Modi H - Search Results

1

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.

Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Skovsø S, et al. Among authors: modi h. Nat Commun. 2022 Feb 8;13(1):735. doi: 10.1038/s41467-022-28039-8. Nat Commun. 2022. PMID: 35136059 Free PMC article.

2

Folding mutations suppress early beta-cell proliferation.

Modi H, Johnson JD. Modi H, et al. Elife. 2018 Dec 14;7:e43475. doi: 10.7554/eLife.43475. Elife. 2018. PMID: 30547883 Free PMC article.

3

Dynamic Ins2 Gene Activity Defines β-Cell Maturity States.

Chu CMJ, Modi H, Ellis C, Krentz NAJ, Skovsø S, Zhao YB, Cen H, Noursadeghi N, Panzhinskiy E, Hu X, Dionne DA, Xia YH, Xuan S, Huising MO, Kieffer TJ, Lynn FC, Johnson JD. Chu CMJ, et al. Among authors: modi h. Diabetes. 2022 Dec 1;71(12):2612-2631. doi: 10.2337/db21-1065. Diabetes. 2022. PMID: 36170671

4

High-content screening identifies a role for Na(+) channels in insulin production.

Szabat M, Modi H, Ramracheya R, Girbinger V, Chan F, Lee JT, Piske M, Kamal S, Carol Yang YH, Welling A, Rorsman P, Johnson JD. Szabat M, et al. Among authors: modi h. R Soc Open Sci. 2015 Dec 2;2(12):150306. doi: 10.1098/rsos.150306. eCollection 2015 Dec. R Soc Open Sci. 2015. PMID: 27019722 Free PMC article.

5

Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function.

Modi H, Jacovetti C, Tarussio D, Metref S, Madsen OD, Zhang FP, Rantakari P, Poutanen M, Nef S, Gorman T, Regazzi R, Thorens B. Modi H, et al. Diabetes. 2015 Dec;64(12):4148-57. doi: 10.2337/db14-1735. Epub 2015 Sep 17. Diabetes. 2015. PMID: 26384384

6

Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.

Cornu M, Modi H, Kawamori D, Kulkarni RN, Joffraud M, Thorens B. Cornu M, et al. Among authors: modi h. J Biol Chem. 2010 Apr 2;285(14):10538-45. doi: 10.1074/jbc.M109.091116. Epub 2010 Feb 9. J Biol Chem. 2010. PMID: 20145256 Free PMC article.

7

Glutamine stimulates biosynthesis and secretion of insulin-like growth factor 2 (IGF2), an autocrine regulator of beta cell mass and function.

Modi H, Cornu M, Thorens B. Modi H, et al. J Biol Chem. 2014 Nov 14;289(46):31972-31982. doi: 10.1074/jbc.M114.587733. Epub 2014 Sep 30. J Biol Chem. 2014. PMID: 25271169 Free PMC article.

8

Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines and thieno[2,3-b]pyridines.

Bahekar RH, Jain MR, Jadav PA, Prajapati VM, Patel DN, Gupta AA, Sharma A, Tom R, Bandyopadhya D, Modi H, Patel PR. Bahekar RH, et al. Among authors: modi h. Bioorg Med Chem. 2007 Nov 1;15(21):6782-95. doi: 10.1016/j.bmc.2007.08.005. Epub 2007 Aug 10. Bioorg Med Chem. 2007. PMID: 17723306

9

Synthesis of 3,8,9-trisubstituted-1,7,9-triaza-fluorene-6-carboxylic acid derivatives as a new class of insulin secretagogues.

Bahekar RH, Jain MR, Jadav PA, Goel A, Patel DN, Prajapati VM, Gupta AA, Modi H, Patel PR. Bahekar RH, et al. Among authors: modi h. Bioorg Med Chem. 2007 Sep 1;15(17):5950-64. doi: 10.1016/j.bmc.2007.05.075. Epub 2007 Jun 8. Bioorg Med Chem. 2007. PMID: 17583514

10

Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor beta (TR-beta) selective ligands.

Raval S, Raval P, Bandyopadhyay D, Soni K, Yevale D, Jogiya D, Modi H, Joharapurkar A, Gandhi N, Jain MR, Patel PR. Raval S, et al. Among authors: modi h. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3919-24. doi: 10.1016/j.bmcl.2008.06.038. Epub 2008 Jun 14. Bioorg Med Chem Lett. 2008. PMID: 18585912

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