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Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.
Dhaliwal NK, Weng OY, Dong X, Bhattacharya A, Ahmed M, Nishimura H, Choi WWY, Aggarwal A, Luikart BW, Shu Q, Li X, Wilson MD, Moffat J, Wang LY, Muffat J, Li Y. Dhaliwal NK, et al. Among authors: moffat j. Cell Rep. 2024 May 2;43(5):114173. doi: 10.1016/j.celrep.2024.114173. Online ahead of print. Cell Rep. 2024. PMID: 38700984
Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses.
Bessières M, Roy V, Abuduani T, Favetta P, Snoeck R, Andrei G, Moffat J, Gallardo F, Agrofoglio LA. Bessières M, et al. Among authors: moffat j. Eur J Med Chem. 2024 Apr 15;271:116412. doi: 10.1016/j.ejmech.2024.116412. Online ahead of print. Eur J Med Chem. 2024. PMID: 38643669 Free article.
Salmonella exploits membrane reservoirs for invasion of host cells.
Zhu H, Sydor AM, Boddy KC, Coyaud E, Laurent EMN, Au A, Tan JMJ, Yan BR, Moffat J, Muise AM, Yip CM, Grinstein S, Raught B, Brumell JH. Zhu H, et al. Among authors: moffat j. Nat Commun. 2024 Apr 10;15(1):3120. doi: 10.1038/s41467-024-47183-x. Nat Commun. 2024. PMID: 38600106 Free PMC article.
467 results