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Exotoxin-Targeted Drug Modalities as Antibiotic Alternatives.
ACS Infect Dis. 2022 Mar 11;8(3):433-456. doi: 10.1021/acsinfecdis.1c00296. Epub 2022 Jan 31.
ACS Infect Dis. 2022.
PMID: 35099182
Free PMC article.
Review.
Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo.
Ernst K, Mittler AK, Winkelmann V, Kling C, Eberhardt N, Anastasia A, Sonnabend M, Lochbaum R, Wirsching J, Sakari M, Pulliainen AT, Skerry C, Carbonetti NH, Frick M, Barth H.
Ernst K, et al. Among authors: sakari m.
Sci Rep. 2021 Mar 8;11(1):5429. doi: 10.1038/s41598-021-84817-2.
Sci Rep. 2021.
PMID: 33686161
Free PMC article.
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Crystal structures of pertussis toxin with NAD+ and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity.
Sakari M, Tran MT, Rossjohn J, Pulliainen AT, Beddoe T, Littler DR.
Sakari M, et al.
J Biol Chem. 2022 May;298(5):101892. doi: 10.1016/j.jbc.2022.101892. Epub 2022 Apr 1.
J Biol Chem. 2022.
PMID: 35378130
Free PMC article.
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