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Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.
Jung CB, Moretti A, Mederos y Schnitzler M, Iop L, Storch U, Bellin M, Dorn T, Ruppenthal S, Pfeiffer S, Goedel A, Dirschinger RJ, Seyfarth M, Lam JT, Sinnecker D, Gudermann T, Lipp P, Laugwitz KL. Jung CB, et al. Among authors: moretti a. EMBO Mol Med. 2012 Mar;4(3):180-91. doi: 10.1002/emmm.201100194. Epub 2012 Jan 25. EMBO Mol Med. 2012. PMID: 22174035 Free PMC article.
Induced pluripotent stem cells in cardiovascular research.
Sinnecker D, Dirschinger RJ, Goedel A, Moretti A, Lipp P, Laugwitz KL. Sinnecker D, et al. Among authors: moretti a. Rev Physiol Biochem Pharmacol. 2012;163:1-26. doi: 10.1007/112_2012_6. Rev Physiol Biochem Pharmacol. 2012. PMID: 22447279 Review.
Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.
Rocchetti M, Sala L, Dreizehnter L, Crotti L, Sinnecker D, Mura M, Pane LS, Altomare C, Torre E, Mostacciuolo G, Severi S, Porta A, De Ferrari GM, George AL Jr, Schwartz PJ, Gnecchi M, Moretti A, Zaza A. Rocchetti M, et al. Among authors: moretti a. Cardiovasc Res. 2017 Apr 1;113(5):531-541. doi: 10.1093/cvr/cvx006. Cardiovasc Res. 2017. PMID: 28158429
Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.
Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D. Chen Z, et al. Among authors: moretti a. Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. Eur Heart J. 2017. PMID: 28182242 Free PMC article.
Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models.
Schweitzer MK, Wilting F, Sedej S, Dreizehnter L, Dupper NJ, Tian Q, Moretti A, My I, Kwon O, Priori SG, Laugwitz KL, Storch U, Lipp P, Breit A, Mederos Y Schnitzler M, Gudermann T, Schredelseker J. Schweitzer MK, et al. Among authors: moretti a. JACC Basic Transl Sci. 2017 Dec;2(6):737-747. doi: 10.1016/j.jacbts.2017.06.008. Epub 2017 Nov 8. JACC Basic Transl Sci. 2017. PMID: 29354781 Free PMC article.
Modeling long-QT syndromes with iPS cells.
Sinnecker D, Goedel A, Dorn T, Dirschinger RJ, Moretti A, Laugwitz KL. Sinnecker D, et al. Among authors: moretti a. J Cardiovasc Transl Res. 2013 Feb;6(1):31-6. doi: 10.1007/s12265-012-9416-1. Epub 2012 Oct 18. J Cardiovasc Transl Res. 2013. PMID: 23076501 Review.
875 results