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Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C.
Colaco A, Fernández-Suárez ME, Shepherd D, Gal L, Bibi C, Chuartzman S, Diot A, Morten K, Eden E, Porter FD, Poulton J, Platt N, Schuldiner M, Platt FM. Colaco A, et al. Among authors: morten k. Life Sci Alliance. 2020 Jun 2;3(7):e201800253. doi: 10.26508/lsa.201800253. Print 2020 Jul. Life Sci Alliance. 2020. PMID: 32487688 Free PMC article.
Mitophagy plays a central role in mitochondrial ageing.
Diot A, Morten K, Poulton J. Diot A, et al. Among authors: morten k. Mamm Genome. 2016 Aug;27(7-8):381-95. doi: 10.1007/s00335-016-9651-x. Epub 2016 Jun 28. Mamm Genome. 2016. PMID: 27352213 Free PMC article. Review.
Acetyl-leucine slows disease progression in lysosomal storage disorders.
Kaya E, Smith DA, Smith C, Morris L, Bremova-Ertl T, Cortina-Borja M, Fineran P, Morten KJ, Poulton J, Boland B, Spencer J, Strupp M, Platt FM. Kaya E, et al. Brain Commun. 2020 Dec 20;3(1):fcaa148. doi: 10.1093/braincomms/fcaa148. eCollection 2021. Brain Commun. 2020. PMID: 33738443 Free PMC article.
A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA.
Diot A, Hinks-Roberts A, Lodge T, Liao C, Dombi E, Morten K, Brady S, Fratter C, Carver J, Muir R, Davis R, Green CJ, Johnston I, Hilton-Jones D, Sue C, Mortiboys H, Poulton J. Diot A, et al. Among authors: morten k. Pharmacol Res. 2015 Oct;100:24-35. doi: 10.1016/j.phrs.2015.07.014. Epub 2015 Jul 18. Pharmacol Res. 2015. PMID: 26196248
The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy.
Dombi E, Diot A, Morten K, Carver J, Lodge T, Fratter C, Ng YS, Liao C, Muir R, Blakely EL, Hargreaves I, Al-Dosary M, Sarkar G, Hickman SJ, Downes SM, Jayawant S, Yu-Wai-Man P, Taylor RW, Poulton J. Dombi E, et al. Among authors: morten k. Neurology. 2016 May 17;86(20):1921-3. doi: 10.1212/WNL.0000000000002688. Epub 2016 Apr 22. Neurology. 2016. PMID: 27164671 Free PMC article. No abstract available.
Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation.
Diot A, Agnew T, Sanderson J, Liao C, Carver J, Neves RPD, Gupta R, Guo Y, Waters C, Seto S, Daniels MJ, Dombi E, Lodge T, Morten K, Williams SA, Enver T, Iborra FJ, Votruba M, Poulton J. Diot A, et al. Among authors: morten k. Front Cell Dev Biol. 2018 Sep 19;6:103. doi: 10.3389/fcell.2018.00103. eCollection 2018. Front Cell Dev Biol. 2018. PMID: 30283778 Free PMC article.
74 results