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Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.
Abrahams KA, Cox JAG, Fütterer K, Rullas J, Ortega-Muro F, Loman NJ, Moynihan PJ, Pérez-Herrán E, Jiménez E, Esquivias J, Barros D, Ballell L, Alemparte C, Besra GS. Abrahams KA, et al. Among authors: moynihan pj. Sci Rep. 2017 Aug 25;7(1):9430. doi: 10.1038/s41598-017-09642-y. Sci Rep. 2017. PMID: 28842600 Free PMC article.
Identification of KasA as the cellular target of an anti-tubercular scaffold.
Abrahams KA, Chung CW, Ghidelli-Disse S, Rullas J, Rebollo-López MJ, Gurcha SS, Cox JA, Mendoza A, Jiménez-Navarro E, Martínez-Martínez MS, Neu M, Shillings A, Homes P, Argyrou A, Casanueva R, Loman NJ, Moynihan PJ, Lelièvre J, Selenski C, Axtman M, Kremer L, Bantscheff M, Angulo-Barturen I, Izquierdo MC, Cammack NC, Drewes G, Ballell L, Barros D, Besra GS, Bates RH. Abrahams KA, et al. Among authors: moynihan pj. Nat Commun. 2016 Sep 1;7:12581. doi: 10.1038/ncomms12581. Nat Commun. 2016. PMID: 27581223 Free PMC article.
The hydrolase LpqI primes mycobacterial peptidoglycan recycling.
Moynihan PJ, Cadby IT, Veerapen N, Jankute M, Crosatti M, Mukamolova GV, Lovering AL, Besra GS. Moynihan PJ, et al. Nat Commun. 2019 Jun 14;10(1):2647. doi: 10.1038/s41467-019-10586-2. Nat Commun. 2019. PMID: 31201321 Free PMC article.
The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth.
Franklin A, Layton AJ, Mize T, Salgueiro VC, Sullivan R, Benedict ST, Gurcha SS, Anso I, Besra GS, Banzhaf M, Lovering AL, Williams SJ, Guerin ME, Scott NE, Prados-Rosales R, Lowe EC, Moynihan PJ. Franklin A, et al. Among authors: moynihan pj. bioRxiv [Preprint]. 2023 Oct 26:2023.10.26.563968. doi: 10.1101/2023.10.26.563968. bioRxiv. 2023. PMID: 37961452 Free PMC article. Preprint.
Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation.
Veerapen N, Kharkwal SS, Jervis P, Bhowruth V, Besra AK, North SJ, Haslam SM, Dell A, Hobrath J, Quaid PJ, Moynihan PJ, Cox LR, Kharkwal H, Zauderer M, Besra GS, Porcelli SA. Veerapen N, et al. Among authors: moynihan pj. Bioconjug Chem. 2018 Sep 19;29(9):3161-3173. doi: 10.1021/acs.bioconjchem.8b00484. Epub 2018 Aug 23. Bioconjug Chem. 2018. PMID: 30085659 Free PMC article.
Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease.
Preciado-Llanes L, Aulicino A, Canals R, Moynihan PJ, Zhu X, Jambo N, Nyirenda TS, Kadwala I, Sousa Gerós A, Owen SV, Jambo KC, Kumwenda B, Veerapen N, Besra GS, Gordon MA, Hinton JCD, Napolitani G, Salio M, Simmons A. Preciado-Llanes L, et al. Among authors: moynihan pj. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20717-20728. doi: 10.1073/pnas.2007472117. Epub 2020 Aug 11. Proc Natl Acad Sci U S A. 2020. PMID: 32788367 Free PMC article.
107 results