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Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors.
J Med Chem. 2018 Sep 13;61(17):7785-7795. doi: 10.1021/acs.jmedchem.8b00765. Epub 2018 Aug 30.
J Med Chem. 2018.
PMID: 30125504
Free PMC article.
Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors.
Muthengi A, Wimalasena VK, Yosief HO, Bikowitz MJ, Sigua LH, Wang T, Li D, Gaieb Z, Dhawan G, Liu S, Erickson J, Amaro RE, Schönbrunn E, Qi J, Zhang W.
Muthengi A, et al.
J Med Chem. 2021 May 13;64(9):5787-5801. doi: 10.1021/acs.jmedchem.0c02232. Epub 2021 Apr 19.
J Med Chem. 2021.
PMID: 33872011
Free PMC article.
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Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation.
Zhang X, Pham K, Liu S, Legris M, Muthengi A, Jasinski JP, Zhang W.
Zhang X, et al.
Beilstein J Org Chem. 2016 Oct 18;12:2204-2210. doi: 10.3762/bjoc.12.211. eCollection 2016.
Beilstein J Org Chem. 2016.
PMID: 27829928
Free PMC article.
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[3 + 2] Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones.
Muthengi A, Erickson J, Muriph RE, Zhang W.
Muthengi A, et al.
J Org Chem. 2019 May 3;84(9):5927-5935. doi: 10.1021/acs.joc.9b00448. Epub 2019 Apr 8.
J Org Chem. 2019.
PMID: 30932493
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