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The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects.
Attardi BJ, Hild SA, Koduri S, Pham T, Pessaint L, Engbring J, Till B, Gropp D, Semon A, Reel JR. Attardi BJ, et al. J Steroid Biochem Mol Biol. 2010 Oct;122(4):212-8. doi: 10.1016/j.jsbmb.2010.06.009. Epub 2010 Jun 25. J Steroid Biochem Mol Biol. 2010. PMID: 20599615 Free PMC article.
Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins.
Attardi BJ, Zeleznik A, Simhan H, Chiao JP, Mattison DR, Caritis SN; Obstetric-Fetal Pharmacology Research Unit Network. Attardi BJ, et al. Am J Obstet Gynecol. 2007 Dec;197(6):599.e1-7. doi: 10.1016/j.ajog.2007.05.024. Am J Obstet Gynecol. 2007. PMID: 18060946 Free PMC article.
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