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TMPRSS2 and RNA-Dependent RNA Polymerase Are Effective Targets of Therapeutic Intervention for Treatment of COVID-19 Caused by SARS-CoV-2 Variants (B.1.1.7 and B.1.351).
Microbiol Spectr. 2021 Sep 3;9(1):e0047221. doi: 10.1128/Spectrum.00472-21. Epub 2021 Aug 11.
Microbiol Spectr. 2021.
PMID: 34378968
Free PMC article.
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion.
Kim TY, Jeon S, Jang Y, Gotina L, Won J, Ju YH, Kim S, Jang MW, Won W, Park MG, Pae AN, Han S, Kim S, Lee CJ.
Kim TY, et al.
Exp Mol Med. 2021 May;53(5):956-972. doi: 10.1038/s12276-021-00624-9. Epub 2021 May 25.
Exp Mol Med. 2021.
PMID: 34035463
Free PMC article.
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