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Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD.
Neuropharmacology. 2020 Jan 1;162:107812. doi: 10.1016/j.neuropharm.2019.107812. Epub 2019 Oct 14.
Neuropharmacology. 2020.
PMID: 31622602
Reduced cell size, chromosomal aberration and altered proliferation rates are characteristics and confounding factors in the STHdh cell model of Huntington disease.
Singer E, Walter C, Weber JJ, Krahl AC, Mau-Holzmann UA, Rischert N, Riess O, Clemensson LE, Nguyen HP.
Singer E, et al. Among authors: rischert n.
Sci Rep. 2017 Dec 4;7(1):16880. doi: 10.1038/s41598-017-17275-4.
Sci Rep. 2017.
PMID: 29203806
Free PMC article.
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