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Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice.
Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. Janelsins MC, et al. Among authors: narrow wc. Am J Pathol. 2008 Dec;173(6):1768-82. doi: 10.2353/ajpath.2008.080528. Epub 2008 Oct 30. Am J Pathol. 2008. PMID: 18974297 Free PMC article.
Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.
Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Knowlden SA, Wright TW, Bowers WJ. Montgomery SL, et al. Among authors: narrow wc. Am J Pathol. 2011 Oct;179(4):2053-70. doi: 10.1016/j.ajpath.2011.07.001. Epub 2011 Aug 9. Am J Pathol. 2011. PMID: 21835156 Free PMC article.
Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies.
Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ. Montgomery SL, et al. Among authors: narrow wc. Am J Pathol. 2013 Jun;182(6):2285-97. doi: 10.1016/j.ajpath.2013.02.030. Epub 2013 Apr 6. Am J Pathol. 2013. PMID: 23567638 Free PMC article.
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