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Year Number of Results
2004 2
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2007 3
2008 1
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2015 1
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2022 3
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Page 1
Target protein localization and its impact on PROTAC-mediated degradation.
Simpson LM, Glennie L, Brewer A, Zhao JF, Crooks J, Shpiro N, Sapkota GP. Simpson LM, et al. Among authors: shpiro n. Cell Chem Biol. 2022 Oct 20;29(10):1482-1504.e7. doi: 10.1016/j.chembiol.2022.08.004. Epub 2022 Sep 7. Cell Chem Biol. 2022. PMID: 36075213 Free article.
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2.
Liu X, Kalogeropulou AF, Domingos S, Makukhin N, Nirujogi RS, Singh F, Shpiro N, Saalfrank A, Sammler E, Ganley IG, Moreira R, Alessi DR, Ciulli A. Liu X, et al. Among authors: shpiro n. J Am Chem Soc. 2022 Sep 21;144(37):16930-16952. doi: 10.1021/jacs.2c05499. Epub 2022 Aug 25. J Am Chem Soc. 2022. PMID: 36007011 Free PMC article.
Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.
Alsina-Beauchamp D, Escós A, Fajardo P, González-Romero D, Díaz-Mora E, Risco A, Martín-Serrano MA, Del Fresno C, Dominguez-Andrés J, Aparicio N, Zur R, Shpiro N, Brown GD, Ardavín C, Netea MG, Alemany S, Sanz-Ezquerro JJ, Cuenda A. Alsina-Beauchamp D, et al. Among authors: shpiro n. EMBO Mol Med. 2018 May;10(5):e8485. doi: 10.15252/emmm.201708485. EMBO Mol Med. 2018. PMID: 29661910 Free PMC article.
Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.
Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Hunter RW, et al. Among authors: shpiro n. Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014. Chem Biol. 2014. PMID: 25036776 Free PMC article.
32 results