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Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
Cell Metab. 2024 Jan 2;36(1):116-129.e7. doi: 10.1016/j.cmet.2023.12.013.
Cell Metab. 2024.
PMID: 38171331
Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.
Rom O, Liu Y, Finney AC, Ghrayeb A, Zhao Y, Shukha Y, Wang L, Rajanayake KK, Das S, Rashdan NA, Weissman N, Delgadillo L, Wen B, Garcia-Barrio MT, Aviram M, Kevil CG, Yurdagul A Jr, Pattillo CB, Zhang J, Sun D, Hayek T, Gottlieb E, Mor I, Chen YE.
Rom O, et al. Among authors: weissman n.
Redox Biol. 2022 Jun;52:102313. doi: 10.1016/j.redox.2022.102313. Epub 2022 Apr 13.
Redox Biol. 2022.
PMID: 35447412
Free PMC article.
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Fatty liver-mediated glycine restriction impairs glutathione synthesis and causes hypersensitization to acetaminophen.
Ghrayeb A, Agranovich B, Peled D, Finney AC, Abramovich I, Garcia JF, Traylor J, Drucker S, Fernandes SI, Weissman N, Chen YE, Rom O, Mor I, Gottlieb E.
Ghrayeb A, et al. Among authors: weissman n.
bioRxiv [Preprint]. 2023 Jan 18:2023.01.16.524043. doi: 10.1101/2023.01.16.524043.
bioRxiv. 2023.
PMID: 36711913
Free PMC article.
Preprint.
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