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Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
Specker E, Matthes S, Wesolowski R, Schütz A, Grohmann M, Alenina N, Pleimes D, Mallow K, Neuenschwander M, Gogolin A, Weise M, Pfeifer J, Ziebart N, Heinemann U, von Kries JP, Nazaré M, Bader M. Specker E, et al. Among authors: nazare m. J Med Chem. 2022 Aug 25;65(16):11126-11149. doi: 10.1021/acs.jmedchem.2c00598. Epub 2022 Aug 3. J Med Chem. 2022. PMID: 35921615
Temperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures.
Geiger MA, Orwick-Rydmark M, Märker K, Franks WT, Akhmetzyanov D, Stöppler D, Zinke M, Specker E, Nazaré M, Diehl A, van Rossum BJ, Aussenac F, Prisner T, Akbey Ü, Oschkinat H. Geiger MA, et al. Among authors: nazare m. Phys Chem Chem Phys. 2016 Nov 9;18(44):30696-30704. doi: 10.1039/c6cp06154k. Phys Chem Chem Phys. 2016. PMID: 27791210
Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.
Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M. Anumala UR, et al. Among authors: nazare m. J Med Chem. 2017 Dec 28;60(24):10013-10025. doi: 10.1021/acs.jmedchem.7b00883. Epub 2017 Dec 8. J Med Chem. 2017. PMID: 29155568
Allosteric Inhibition of a Mammalian Lectin.
Aretz J, Anumala UR, Fuchsberger FF, Molavi N, Ziebart N, Zhang H, Nazaré M, Rademacher C. Aretz J, et al. Among authors: nazare m. J Am Chem Soc. 2018 Nov 7;140(44):14915-14925. doi: 10.1021/jacs.8b08644. Epub 2018 Oct 24. J Am Chem Soc. 2018. PMID: 30303367
A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy.
Marcinkowski P, Hoyer I, Specker E, Furkert J, Rutz C, Neuenschwander M, Sobottka S, Sun H, Nazare M, Berchner-Pfannschmidt U, von Kries JP, Eckstein A, Schülein R, Krause G. Marcinkowski P, et al. Among authors: nazare m. Thyroid. 2019 Jan;29(1):111-123. doi: 10.1089/thy.2018.0349. Epub 2018 Dec 15. Thyroid. 2019. PMID: 30351237
CellFy: A Cell-Based Fragment Screen against C-Type Lectins.
Schulze J, Baukmann H, Wawrzinek R, Fuchsberger FF, Specker E, Aretz J, Nazaré M, Rademacher C. Schulze J, et al. Among authors: nazare m. ACS Chem Biol. 2018 Dec 21;13(12):3229-3235. doi: 10.1021/acschembio.8b00875. Epub 2018 Dec 3. ACS Chem Biol. 2018. PMID: 30480432
Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.
Klein W, Rutz C, Eckhard J, Provinciael B, Specker E, Neuenschwander M, Kleinau G, Scheerer P, von Kries JP, Nazaré M, Vermeire K, Schülein R. Klein W, et al. Among authors: nazare m. PLoS One. 2018 Dec 13;13(12):e0208641. doi: 10.1371/journal.pone.0208641. eCollection 2018. PLoS One. 2018. PMID: 30543669 Free PMC article.
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.
Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P. Brennecke P, et al. Among authors: nazare m. SLAS Discov. 2019 Mar;24(3):398-413. doi: 10.1177/2472555218816276. Epub 2019 Jan 7. SLAS Discov. 2019. PMID: 30616481 Free PMC article.
91 results