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Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
Specker E, Matthes S, Wesolowski R, Schütz A, Grohmann M, Alenina N, Pleimes D, Mallow K, Neuenschwander M, Gogolin A, Weise M, Pfeifer J, Ziebart N, Heinemann U, von Kries JP, Nazaré M, Bader M. Specker E, et al. Among authors: neuenschwander m. J Med Chem. 2022 Aug 25;65(16):11126-11149. doi: 10.1021/acs.jmedchem.2c00598. Epub 2022 Aug 3. J Med Chem. 2022. PMID: 35921615
Small-molecule screening identifies modulators of aquaporin-2 trafficking.
Bogum J, Faust D, Zühlke K, Eichhorst J, Moutty MC, Furkert J, Eldahshan A, Neuenschwander M, von Kries JP, Wiesner B, Trimpert C, Deen PM, Valenti G, Rosenthal W, Klussmann E. Bogum J, et al. Among authors: neuenschwander m. J Am Soc Nephrol. 2013 Apr;24(5):744-58. doi: 10.1681/ASN.2012030295. Epub 2013 Apr 4. J Am Soc Nephrol. 2013. PMID: 23559583 Free PMC article.
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma.
Du J, Neuenschwander M, Yu Y, Däbritz JH, Neuendorff NR, Schleich K, Bittner A, Milanovic M, Beuster G, Radetzki S, Specker E, Reimann M, Rosenbauer F, Mathas S, Lohneis P, Hummel M, Dörken B, von Kries JP, Lee S, Schmitt CA. Du J, et al. Among authors: neuenschwander m. Blood. 2017 Jan 5;129(1):71-81. doi: 10.1182/blood-2016-02-700773. Epub 2016 Oct 12. Blood. 2017. PMID: 27733358 Free article.
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR. Wetzel C, et al. Among authors: neuenschwander m. Nat Neurosci. 2017 Feb;20(2):209-218. doi: 10.1038/nn.4454. Epub 2016 Dec 12. Nat Neurosci. 2017. PMID: 27941788
Small Molecules Targeting Human N-Acetylmannosamine Kinase.
Hinderlich S, Neuenschwander M, Wratil PR, Oder A, Lisurek M, Nguyen LD, von Kries JP, Hackenberger CPR. Hinderlich S, et al. Among authors: neuenschwander m. Chembiochem. 2017 Jul 4;18(13):1279-1285. doi: 10.1002/cbic.201700066. Epub 2017 Apr 27. Chembiochem. 2017. PMID: 28346741
Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.
Juneja M, Kobelt D, Walther W, Voss C, Smith J, Specker E, Neuenschwander M, Gohlke BO, Dahlmann M, Radetzki S, Preissner R, von Kries JP, Schlag PM, Stein U. Juneja M, et al. Among authors: neuenschwander m. PLoS Biol. 2017 Jun 1;15(6):e2000784. doi: 10.1371/journal.pbio.2000784. eCollection 2017 Jun. PLoS Biol. 2017. PMID: 28570591 Free PMC article.
114 results