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Page 1
Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy.
Singh A, Kazer SW, Roider J, Krista KC, Millar J, Asowata OE, Ngoepe A, Ramsuran D, Fardoos R, Ardain A, Muenchhoff M, Kuhn W, Karim F, Ndung'u T, Shalek AK, Goulder P, Leslie A, Kløverpris HN. Singh A, et al. Among authors: ngoepe a. Cell Rep. 2020 Sep 15;32(11):108153. doi: 10.1016/j.celrep.2020.108153. Cell Rep. 2020. PMID: 32937142 Free PMC article.
High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults.
Roider J, Maehara T, Ngoepe A, Ramsuran D, Muenchhoff M, Adland E, Aicher T, Kazer SW, Jooste P, Karim F, Kuhn W, Shalek AK, Ndung'u T, Morris L, Moore PL, Pillai S, Kløverpris H, Goulder P, Leslie A. Roider J, et al. Among authors: ngoepe a. Front Immunol. 2018 Sep 12;9:1975. doi: 10.3389/fimmu.2018.01975. eCollection 2018. Front Immunol. 2018. PMID: 30258437 Free PMC article. Clinical Trial.
Irreversible depletion of intestinal CD4+ T cells is associated with T cell activation during chronic HIV infection.
Asowata OE, Singh A, Ngoepe A, Herbert N, Fardoos R, Reddy K, Zungu Y, Nene F, Mthabela N, Ramjit D, Karim F, Govender K, Ndung'u T, Porterfield JZ, Adamson JH, Madela FG, Manzini VT, Anderson F, Leslie A, Kløverpris HN. Asowata OE, et al. Among authors: ngoepe a. JCI Insight. 2021 Nov 22;6(22):e146162. doi: 10.1172/jci.insight.146162. JCI Insight. 2021. PMID: 34618690 Free PMC article.
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells.
Fardoos R, Asowata OE, Herbert N, Nyquist SK, Zungu Y, Singh A, Ngoepe A, Mbano IM, Mthabela N, Ramjit D, Karim F, Kuhn W, Madela FG, Manzini VT, Anderson F, Berger B, Pers TH, Shalek AK, Leslie A, Kløverpris HN. Fardoos R, et al. Among authors: ngoepe a. JCI Insight. 2021 Aug 23;6(16):e148920. doi: 10.1172/jci.insight.148920. JCI Insight. 2021. PMID: 34252054 Free PMC article.
T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy.
Lustig G, Cele S, Karim F, Derache A, Ngoepe A, Khan K, Gosnell BI, Moosa MS, Ntshuba N, Marais S, Jeena PM, Govender K, Adamson J, Kløverpris H, Gupta RK, Harrichandparsad R, Patel VB, Sigal A. Lustig G, et al. Among authors: ngoepe a. PLoS Pathog. 2021 Sep 23;17(9):e1009871. doi: 10.1371/journal.ppat.1009871. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34555123 Free PMC article.
Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung.
Ogongo P, Tezera LB, Ardain A, Nhamoyebonde S, Ramsuran D, Singh A, Ng'oepe A, Karim F, Naidoo T, Khan K, Dullabh KJ, Fehlings M, Lee BH, Nardin A, Lindestam Arlehamn CS, Sette A, Behar SM, Steyn AJ, Madansein R, Kløverpris HN, Elkington PT, Leslie A. Ogongo P, et al. J Clin Invest. 2021 May 17;131(10):e142014. doi: 10.1172/JCI142014. J Clin Invest. 2021. PMID: 33848273 Free PMC article. Clinical Trial.
Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection.
Ndlovu LN, Peetluk L, Moodley S, Nhamoyebonde S, Ngoepe AT, Mazibuko M, Khan K, Karim F, Pym AS, Maruri F, Moosa MS, van der Heijden YF, Sterling TR, Leslie A. Ndlovu LN, et al. Among authors: ngoepe at. Front Immunol. 2020 Aug 28;11:1872. doi: 10.3389/fimmu.2020.01872. eCollection 2020. Front Immunol. 2020. PMID: 32983107 Free PMC article.
HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control.
Fardoos R, Nyquist SK, Asowata OE, Kazer SW, Singh A, Ngoepe A, Giandhari J, Mthabela N, Ramjit D, Singh S, Karim F, Buus S, Anderson F, Porterfield JZ, Sibiya AL, Bipath R, Moodley K, Kuhn W, Berger B, Nguyen S, de Oliveira T, Ndung'u T, Goulder P, Shalek AK, Leslie A, Kløverpris HN. Fardoos R, et al. Among authors: ngoepe a. Front Immunol. 2022 Oct 18;13:912038. doi: 10.3389/fimmu.2022.912038. eCollection 2022. Front Immunol. 2022. PMID: 36330531 Free PMC article.
HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway.
Krause R, Snyman J, Shi-Hsia H, Muema D, Karim F, Ganga Y, Ngoepe A, Zungu Y, Gazy I, Bernstein M, Khan K, Mazibuko M, Mthabela N, Ramjit D; COMMIT-KZN Team; Limbo O, Jardine J, Sok D, Wilson IA, Hanekom W, Sigal A, Kløverpris H, Ndung'u T, Leslie A. Krause R, et al. Among authors: ngoepe a. Elife. 2022 Oct 27;11:e79924. doi: 10.7554/eLife.79924. Elife. 2022. PMID: 36300787 Free PMC article.