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Assay, Purity, and Impurity Profile of Phosphorothioate Oligonucleotide Therapeutics by Ion Pair-HPLC-MS.
Nucleic Acid Ther. 2022 Jun;32(3):206-220. doi: 10.1089/nat.2021.0056. Epub 2022 Mar 2.
Nucleic Acid Ther. 2022.
PMID: 35238617
Impurity Qualification Toxicology Study for a 2'-O-Methoxyethyl-Modified Antisense Inhibitor in Mice.
Kim TW, Papagiannis C, Capaldi D, McPherson AK, Mahdi F, Luu N, Rodriguez AA, Hoffmaster C, Serota D, Henry SP.
Kim TW, et al. Among authors: luu n.
Nucleic Acid Ther. 2020 Feb;30(1):14-21. doi: 10.1089/nat.2019.0780. Epub 2019 Nov 5.
Nucleic Acid Ther. 2020.
PMID: 31687889
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Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides.
Kurata C, Bradley K, Gaus H, Luu N, Cedillo I, Ravikumar VT, Van Sooy K, McArdle JV, Capaldi DC.
Kurata C, et al. Among authors: luu n.
Bioorg Med Chem Lett. 2006 Feb;16(3):607-14. doi: 10.1016/j.bmcl.2005.10.051. Epub 2005 Nov 7.
Bioorg Med Chem Lett. 2006.
PMID: 16274991
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