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Page 1
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol Cell. 2023 Mar 2;83(5):770-786.e9. doi: 10.1016/j.molcel.2023.01.019. Epub 2023 Feb 16.
Mol Cell. 2023.
PMID: 36805027
Free PMC article.
Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G.
Li J, et al. Among authors: purser n.
Mol Cell. 2024 Apr 4;84(7):1304-1320.e16. doi: 10.1016/j.molcel.2024.01.022. Epub 2024 Feb 20.
Mol Cell. 2024.
PMID: 38382526
Free PMC article.
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Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases.
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist DT, Scott DC, Steigenberger B, Prabu JR, Schulman BA, Kleiger G.
Liwocha J, et al. Among authors: purser n.
Nat Struct Mol Biol. 2024 Feb;31(2):378-389. doi: 10.1038/s41594-023-01206-1. Epub 2024 Feb 7.
Nat Struct Mol Biol. 2024.
PMID: 38326650
Free PMC article.
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Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase.
Purser N, Tripathi-Giesgen I, Li J, Scott DC, Horn-Ghetko D, Baek K, Schulman BA, Alpi AF, Kleiger G.
Purser N, et al.
Biochem J. 2023 Nov 29;480(22):1817-1831. doi: 10.1042/BCJ20230373.
Biochem J. 2023.
PMID: 37870100
Free PMC article.
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Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA.
Liwocha J, et al. Among authors: purser n.
Nat Chem Biol. 2021 Mar;17(3):272-279. doi: 10.1038/s41589-020-00696-0. Epub 2020 Dec 7.
Nat Chem Biol. 2021.
PMID: 33288957
Free PMC article.
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