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2015 1
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2018 4
2020 2
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2023 3
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15 results

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Page 1
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Green AC, Marttila P, Kiweler N, Chalkiadaki C, Wiita E, Cookson V, Lesur A, Eiden K, Bernardin F, Vallin KSA, Borhade S, Long M, Ghahe EK, Jiménez-Alonso JJ, Jemth AS, Loseva O, Mortusewicz O, Meyers M, Viry E, Johansson AI, Hodek O, Homan E, Bonagas N, Ramos L, Sandberg L, Frödin M, Moussay E, Slipicevic A, Letellier E, Paggetti J, Sørensen CS, Helleday T, Henriksson M, Meiser J. Green AC, et al. Among authors: kiweler n. Nat Metab. 2023 Apr;5(4):642-659. doi: 10.1038/s42255-023-00771-5. Epub 2023 Apr 3. Nat Metab. 2023. PMID: 37012496 Free PMC article.
Formate promotes invasion and metastasis in reliance on lipid metabolism.
Delbrouck C, Kiweler N, Chen O, Pozdeev VI, Haase L, Neises L, Oudin A, Fouquier d'Hérouël A, Shen R, Schlicker L, Halder R, Lesur A, Schuster A, Lorenz NI, Jaeger C, Feucherolles M, Frache G, Szpakowska M, Chevigne A, Ronellenfitsch MW, Moussay E, Piraud M, Skupin A, Schulze A, Niclou SP, Letellier E, Meiser J. Delbrouck C, et al. Among authors: kiweler n. Cell Rep. 2023 Sep 26;42(9):113034. doi: 10.1016/j.celrep.2023.113034. Epub 2023 Aug 30. Cell Rep. 2023. PMID: 37651228 Free article.
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis.
Kiweler N, Delbrouck C, Pozdeev VI, Neises L, Soriano-Baguet L, Eiden K, Xian F, Benzarti M, Haase L, Koncina E, Schmoetten M, Jaeger C, Noman MZ, Vazquez A, Janji B, Dittmar G, Brenner D, Letellier E, Meiser J. Kiweler N, et al. Nat Commun. 2022 May 16;13(1):2699. doi: 10.1038/s41467-022-30363-y. Nat Commun. 2022. PMID: 35577770 Free PMC article.
Interstrand Crosslink Repair as a Target for HDAC Inhibition.
Nikolova T, Kiweler N, Krämer OH. Nikolova T, et al. Among authors: kiweler n. Trends Pharmacol Sci. 2017 Sep;38(9):822-836. doi: 10.1016/j.tips.2017.05.009. Epub 2017 Jul 4. Trends Pharmacol Sci. 2017. PMID: 28687272 Review.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Bonagas N, Gustafsson NMS, Henriksson M, Marttila P, Gustafsson R, Wiita E, Borhade S, Green AC, Vallin KSA, Sarno A, Svensson R, Göktürk C, Pham T, Jemth AS, Loseva O, Cookson V, Kiweler N, Sandberg L, Rasti A, Unterlass JE, Haraldsson M, Andersson Y, Scaletti ER, Bengtsson C, Paulin CBJ, Sanjiv K, Abdurakhmanov E, Pudelko L, Kunz B, Desroses M, Iliev P, Färnegårdh K, Krämer A, Garg N, Michel M, Häggblad S, Jarvius M, Kalderén C, Jensen AB, Almlöf I, Karsten S, Zhang SM, Häggblad M, Eriksson A, Liu J, Glinghammar B, Nekhotiaeva N, Klingegård F, Koolmeister T, Martens U, Llona-Minguez S, Moulson R, Nordström H, Parrow V, Dahllund L, Sjöberg B, Vargas IL, Vo DD, Wannberg J, Knapp S, Krokan HE, Arvidsson PI, Scobie M, Meiser J, Stenmark P, Berglund UW, Homan EJ, Helleday T. Bonagas N, et al. Among authors: kiweler n. Nat Cancer. 2022 Feb;3(2):156-172. doi: 10.1038/s43018-022-00331-y. Epub 2022 Feb 28. Nat Cancer. 2022. PMID: 35228749 Free PMC article.
Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.
Wagner T, Kiweler N, Wolff K, Knauer SK, Brandl A, Hemmerich P, Dannenberg JH, Heinzel T, Schneider G, Krämer OH. Wagner T, et al. Among authors: kiweler n. Oncotarget. 2015 Mar 30;6(9):7123-35. doi: 10.18632/oncotarget.3344. Oncotarget. 2015. PMID: 25704882 Free PMC article.
Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.
Schäfer C, Göder A, Beyer M, Kiweler N, Mahendrarajah N, Rauch A, Nikolova T, Stojanovic N, Wieczorek M, Reich TR, Tomicic MT, Linnebacher M, Sonnemann J, Dietrich S, Sellmer A, Mahboobi S, Heinzel T, Schneider G, Krämer OH. Schäfer C, et al. Among authors: kiweler n. Cell Signal. 2017 Jan;29:218-225. doi: 10.1016/j.cellsig.2016.11.002. Epub 2016 Nov 9. Cell Signal. 2017. PMID: 27838375
15 results