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Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.
Sandborn WJ, Ghosh S, Panes J, Vranic I, Su C, Rousell S, Niezychowski W; Study A3921063 Investigators. Sandborn WJ, et al. Among authors: niezychowski w. N Engl J Med. 2012 Aug 16;367(7):616-24. doi: 10.1056/NEJMoa1112168. N Engl J Med. 2012. PMID: 22894574 Free article. Clinical Trial.
Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis.
Sandborn WJ, Su C, Sands BE, D'Haens GR, Vermeire S, Schreiber S, Danese S, Feagan BG, Reinisch W, Niezychowski W, Friedman G, Lawendy N, Yu D, Woodworth D, Mukherjee A, Zhang H, Healey P, Panés J; OCTAVE Induction 1, OCTAVE Induction 2, and OCTAVE Sustain Investigators. Sandborn WJ, et al. Among authors: niezychowski w. N Engl J Med. 2017 May 4;376(18):1723-1736. doi: 10.1056/NEJMoa1606910. N Engl J Med. 2017. PMID: 28467869 Free article. Clinical Trial.
Agreement between local and central reading of endoscopic disease activity in ulcerative colitis: results from the tofacitinib OCTAVE trials.
Feagan BG, Khanna R, Sandborn WJ, Vermeire S, Reinisch W, Su C, Salese L, Fan H, Paulissen J, Woodworth DA, Niezychowski W, Sands BE. Feagan BG, et al. Among authors: niezychowski w. Aliment Pharmacol Ther. 2021 Dec;54(11-12):1442-1453. doi: 10.1111/apt.16626. Epub 2021 Oct 6. Aliment Pharmacol Ther. 2021. PMID: 34614208 Free PMC article.
Tofacitinib for induction and maintenance therapy of Crohn's disease: results of two phase IIb randomised placebo-controlled trials.
Panés J, Sandborn WJ, Schreiber S, Sands BE, Vermeire S, D'Haens G, Panaccione R, Higgins PDR, Colombel JF, Feagan BG, Chan G, Moscariello M, Wang W, Niezychowski W, Marren A, Healey P, Maller E. Panés J, et al. Among authors: niezychowski w. Gut. 2017 Jun;66(6):1049-1059. doi: 10.1136/gutjnl-2016-312735. Epub 2017 Feb 16. Gut. 2017. PMID: 28209624 Free PMC article. Clinical Trial.
Challenges and Opportunities in IBD Clinical Trial Design.
Dubinsky MC, Collins R, Abreu MT; International Organization for the Study of Inflammatory Bowel Diseases (IOIBD). Dubinsky MC, et al. Gastroenterology. 2021 Aug;161(2):400-404. doi: 10.1053/j.gastro.2021.03.065. Epub 2021 Apr 20. Gastroenterology. 2021. PMID: 33864796 Free article. No abstract available.
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