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A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.
Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biesen T, Cartmell J, Bianchi B, Niforatos W, Kage K, Yu H, Mikusa J, Wismer CT, Zhu CZ, Chu K, Lee CH, Stewart AO, Polakowski J, Cox BF, Kowaluk E, Williams M, Sullivan J, Faltynek C. Jarvis MF, et al. Among authors: niforatos w. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84. doi: 10.1073/pnas.252537299. Epub 2002 Dec 13. Proc Natl Acad Sci U S A. 2002. PMID: 12482951 Free PMC article.
P2X receptor-mediated ionic currents in dorsal root ganglion neurons.
Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, Jarvis MF. Burgard EC, et al. Among authors: niforatos w. J Neurophysiol. 1999 Sep;82(3):1590-8. doi: 10.1152/jn.1999.82.3.1590. J Neurophysiol. 1999. PMID: 10482772 Free article.
Molecular and functional characterization of human P2X(2) receptors.
Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF. Lynch KJ, et al. Among authors: niforatos w. Mol Pharmacol. 1999 Dec;56(6):1171-81. doi: 10.1124/mol.56.6.1171. Mol Pharmacol. 1999. PMID: 10570044
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid.
El Kouhen R, Surowy CS, Bianchi BR, Neelands TR, McDonald HA, Niforatos W, Gomtsyan A, Lee CH, Honore P, Sullivan JP, Jarvis MF, Faltynek CR. El Kouhen R, et al. Among authors: niforatos w. J Pharmacol Exp Ther. 2005 Jul;314(1):400-9. doi: 10.1124/jpet.105.084103. Epub 2005 Apr 18. J Pharmacol Exp Ther. 2005. PMID: 15837819
27 results