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De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.
Kirov G, Pocklington AJ, Holmans P, Ivanov D, Ikeda M, Ruderfer D, Moran J, Chambert K, Toncheva D, Georgieva L, Grozeva D, Fjodorova M, Wollerton R, Rees E, Nikolov I, van de Lagemaat LN, Bayés A, Fernandez E, Olason PI, Böttcher Y, Komiyama NH, Collins MO, Choudhary J, Stefansson K, Stefansson H, Grant SG, Purcell S, Sklar P, O'Donovan MC, Owen MJ. Kirov G, et al. Among authors: nikolov i. Mol Psychiatry. 2012 Feb;17(2):142-53. doi: 10.1038/mp.2011.154. Epub 2011 Nov 15. Mol Psychiatry. 2012. PMID: 22083728 Free PMC article.
Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain.
Richards AL, Jones L, Moskvina V, Kirov G, Gejman PV, Levinson DF, Sanders AR; Molecular Genetics of Schizophrenia Collaboration (MGS); International Schizophrenia Consortium (ISC); Purcell S, Visscher PM, Craddock N, Owen MJ, Holmans P, O'Donovan MC. Richards AL, et al. Mol Psychiatry. 2012 Feb;17(2):193-201. doi: 10.1038/mp.2011.11. Epub 2011 Feb 22. Mol Psychiatry. 2012. PMID: 21339752 Free PMC article.
A genome-wide association study in 574 schizophrenia trios using DNA pooling.
Kirov G, Zaharieva I, Georgieva L, Moskvina V, Nikolov I, Cichon S, Hillmer A, Toncheva D, Owen MJ, O'Donovan MC. Kirov G, et al. Among authors: nikolov i. Mol Psychiatry. 2009 Aug;14(8):796-803. doi: 10.1038/mp.2008.33. Epub 2008 Mar 11. Mol Psychiatry. 2009. PMID: 18332876
Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.
O'Donovan MC, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Giegling I, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Adolfsson R, Osby U, Terenius L, Jönsson EG, Cichon S, Nöthen MM, Gill M, Corvin AP, Rujescu D, Gejman PV, Kirov G, Craddock N, Williams NM, Owen MJ; Molecular Genetics of Schizophrenia Collaboration. O'Donovan MC, et al. Among authors: nikolov i. Mol Psychiatry. 2009 Jan;14(1):30-6. doi: 10.1038/mp.2008.108. Epub 2008 Sep 23. Mol Psychiatry. 2009. PMID: 18813210 Free PMC article.
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E; Wellcome Trust Case Control Consortium; Owen MJ, O'Donovan MC. Moskvina V, et al. Among authors: nikolov i. Mol Psychiatry. 2009 Mar;14(3):252-60. doi: 10.1038/mp.2008.133. Epub 2008 Dec 9. Mol Psychiatry. 2009. PMID: 19065143 Free PMC article.
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.
Craddock N, Jones L, Jones IR, Kirov G, Green EK, Grozeva D, Moskvina V, Nikolov I, Hamshere ML, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Norton N, Breen G, St Clair D, Collier DA, Young AH, Ferrier IN, Farmer A, McGuffin P, Holmans PA; Wellcome Trust Case Control Consortium (WTCCC); Donnelly P, Owen MJ, O'Donovan MC. Craddock N, et al. Among authors: nikolov i. Mol Psychiatry. 2010 Feb;15(2):146-53. doi: 10.1038/mp.2008.66. Epub 2008 Jul 1. Mol Psychiatry. 2010. PMID: 19078961 Free PMC article.
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia.
Green EK, Grozeva D, Jones I, Jones L, Kirov G, Caesar S, Gordon-Smith K, Fraser C, Forty L, Russell E, Hamshere ML, Moskvina V, Nikolov I, Farmer A, McGuffin P; Wellcome Trust Case Control Consortium; Holmans PA, Owen MJ, O'Donovan MC, Craddock N. Green EK, et al. Among authors: nikolov i. Mol Psychiatry. 2010 Oct;15(10):1016-22. doi: 10.1038/mp.2009.49. Epub 2009 Jul 21. Mol Psychiatry. 2010. PMID: 19621016 Free PMC article.
220 results