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UGCG influences glutamine metabolism of breast cancer cells.
Schömel N, Hancock SE, Gruber L, Olzomer EM, Byrne FL, Shah D, Hoehn KL, Turner N, Grösch S, Geisslinger G, Wegner MS. Schömel N, et al. Sci Rep. 2019 Oct 30;9(1):15665. doi: 10.1038/s41598-019-52169-7. Sci Rep. 2019. PMID: 31666638 Free PMC article.
UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells.
Wegner MS, Schömel N, Gruber L, Örtel SB, Kjellberg MA, Mattjus P, Kurz J, Trautmann S, Peng B, Wegner M, Kaulich M, Ahrends R, Geisslinger G, Grösch S. Wegner MS, et al. Among authors: schomel n. Cell Mol Life Sci. 2018 Sep;75(18):3393-3410. doi: 10.1007/s00018-018-2799-7. Epub 2018 Mar 17. Cell Mol Life Sci. 2018. PMID: 29549423
Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells.
Wegner MS, Schömel N, Olzomer EM, Trautmann S, Olesch C, Byrne FL, Brüne B, Gurke R, Ferreirós N, Weigert A, Geisslinger G, Hoehn KL. Wegner MS, et al. Among authors: schomel n. Cell Mol Life Sci. 2021 Nov;78(21-22):7025-7041. doi: 10.1007/s00018-021-03958-9. Epub 2021 Oct 9. Cell Mol Life Sci. 2021. PMID: 34626204 Free PMC article.
GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.
Wegner MS, Gruber L, Schömel N, Trautmann S, Brachtendorf S, Fuhrmann D, Schreiber Y, Olesch C, Brüne B, Geisslinger G, Grösch S. Wegner MS, et al. Among authors: schomel n. Int J Biochem Cell Biol. 2019 Jul;112:95-106. doi: 10.1016/j.biocel.2019.05.002. Epub 2019 May 11. Int J Biochem Cell Biol. 2019. PMID: 31082617
Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.
Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, Meyer Zu Heringdorf D. Vienken H, et al. Among authors: schomel n. Sci Rep. 2017 Mar 6;7:43575. doi: 10.1038/srep43575. Sci Rep. 2017. PMID: 28262793 Free PMC article.