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Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Rehling D, Zhang SM, Jemth AS, Koolmeister T, Throup A, Wallner O, Scaletti E, Moriyama T, Nishii R, Davies J, Desroses M, Rudd SG, Scobie M, Homan E, Berglund UW, Yang JJ, Helleday T, Stenmark P. Rehling D, et al. Among authors: nishii r. J Biol Chem. 2021 Jan-Jun;296:100568. doi: 10.1016/j.jbc.2021.100568. Epub 2021 Mar 19. J Biol Chem. 2021. PMID: 33753169 Free PMC article.
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.
Moriyama T, Nishii R, Perez-Andreu V, Yang W, Klussmann FA, Zhao X, Lin TN, Hoshitsuki K, Nersting J, Kihira K, Hofmann U, Komada Y, Kato M, McCorkle R, Li L, Koh K, Najera CR, Kham SK, Isobe T, Chen Z, Chiew EK, Bhojwani D, Jeffries C, Lu Y, Schwab M, Inaba H, Pui CH, Relling MV, Manabe A, Hori H, Schmiegelow K, Yeoh AE, Evans WE, Yang JJ. Moriyama T, et al. Among authors: nishii r. Nat Genet. 2016 Apr;48(4):367-73. doi: 10.1038/ng.3508. Epub 2016 Feb 15. Nat Genet. 2016. PMID: 26878724 Free PMC article.
Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia.
Zhu Y, Yin D, Su Y, Xia X, Moriyama T, Nishii R, Liao F, Zhang S, Guo X, Hou Q, Ai Y, Zhou X, Sun S, Zhang D, Zhang Y, Lin C, Deng Y, Lu X, Wang Y, Ma Z, Wang H, Liu B, Yang L, Zhang W, Yang JJ, Shu Y, Gao J, Xu H. Zhu Y, et al. Among authors: nishii r. Haematologica. 2018 Jul;103(7):e293-e295. doi: 10.3324/haematol.2018.187658. Epub 2018 Mar 8. Haematologica. 2018. PMID: 29519865 Free PMC article. No abstract available.
Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.
Nishii R, Moriyama T, Janke LJ, Yang W, Suiter CC, Lin TN, Li L, Kihira K, Toyoda H, Hofmann U, Schwab M, Takagi M, Morio T, Manabe A, Kham S, Jiang N, Rabin KR, Kato M, Koh K, Yeoh AE, Hori H, Yang JJ. Nishii R, et al. Blood. 2018 May 31;131(22):2466-2474. doi: 10.1182/blood-2017-11-815506. Epub 2018 Mar 23. Blood. 2018. PMID: 29572377 Free PMC article.
Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms.
Tsujimoto S, Osumi T, Uchiyama M, Shirai R, Moriyama T, Nishii R, Yamada Y, Kudo K, Sekiguchi M, Arakawa Y, Yoshida M, Uchiyama T, Terui K, Ito S, Koh K, Takita J, Ito E, Tomizawa D, Manabe A, Kiyokawa N, Yang JJ, Kato M. Tsujimoto S, et al. Among authors: nishii r. Leukemia. 2018 Dec;32(12):2710-2714. doi: 10.1038/s41375-018-0190-1. Epub 2018 Jul 2. Leukemia. 2018. PMID: 29967377 Free PMC article. No abstract available.
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity.
Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith C, Li L, Bhojwani D, Yuen LYP, Li CK, Li CH, Yang YL, Walker GJ, Goodhand JR, Kennedy NA, Klussmann FA, Bhatia S, Relling MV, Kato M, Hori H, Bhatia P, Ahmad T, Yeoh AEJ, Stenmark P, Fowler DM, Yang JJ. Suiter CC, et al. Among authors: nishii r. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5394-5401. doi: 10.1073/pnas.1915680117. Epub 2020 Feb 24. Proc Natl Acad Sci U S A. 2020. PMID: 32094176 Free PMC article.
An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia.
Tanaka Y, Yeoh AEJ, Moriyama T, Li CK, Kudo K, Arakawa Y, Buaboonnam J, Zhang H, Liu HC, Ariffin H, Chen Z, Kham SKY, Nishii R, Hasegawa D, Fujimura J, Keino D, Kondoh K, Sato A, Ueda T, Yamamoto M, Taneyama Y, Hino M, Takagi M, Ohara A, Ito E, Koh K, Hori H, Manabe A, Yang JJ, Kato M. Tanaka Y, et al. Among authors: nishii r. Haematologica. 2021 Jul 1;106(7):2026-2029. doi: 10.3324/haematol.2020.266320. Haematologica. 2021. PMID: 33504140 Free PMC article. No abstract available.
167 results