Extracellular vesicles as potential tools for regenerative therapy

Jose Antonio Rodriguez-Navarro; Jorge Pascual-Guerra; Silvia Sacristan; Maria Del Carmen Nogales; Juan Antonio Fafián-Labora; Ana O'Loghlen

doi:10.1080/23723556.2020.1809958

Extracellular vesicles as potential tools for regenerative therapy

Mol Cell Oncol. 2020 Sep 8;7(6):1809958. doi: 10.1080/23723556.2020.1809958.

Authors

Jose Antonio Rodriguez-Navarro¹, Jorge Pascual-Guerra¹, Silvia Sacristan¹, Maria Del Carmen Nogales¹, Juan Antonio Fafián-Labora², Ana O'Loghlen²

Affiliations

¹ Instituto Ramón y Cajal de Investigaciones Sanitarias, IRYCIS Neurobiología-Investigación, Madrid, Spain.
² Epigenetics & Cellular Senescence Group, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Abstract

Small extracellular vesicles released by fibroblasts from young human donors diminish lipid peroxidation in senescent cells and in different old mice organs due to their enrichment in Glutathione-S-transferase Mu lipid antioxidant activity.

Keywords: Small extracellular vesicles; aging; glutathione-S-transferase M; lipid peroxidation; senescence.

Grants and funding

This work was supported by the Barts and The London School of Medicine and Dentistry [MGU0497]; Biotechnology and Biological Sciences Research Council [BB/P000223/1]; Instituto de Salud Carlos III [CP19-0010]; Ministerio de Economía, Industria y Competitividad, Gobierno de España [SAF2016-78666R]; Xunta de Galicia [ED481B 2017/117].