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Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease.
Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E. Kikuchi H, et al. Among authors: nomura n. Kidney Int. 2019 Jan;95(1):123-137. doi: 10.1016/j.kint.2018.08.030. Epub 2018 Nov 16. Kidney Int. 2019. PMID: 30455054 Free article.
Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease.
Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S. Furusho T, et al. Among authors: nomura n. Kidney Int. 2020 Apr;97(4):713-727. doi: 10.1016/j.kint.2019.11.021. Epub 2020 Feb 11. Kidney Int. 2020. PMID: 32059997 Free article.
Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.
Zeniya M, Morimoto N, Takahashi D, Mori Y, Mori T, Ando F, Araki Y, Yoshizaki Y, Inoue Y, Isobe K, Nomura N, Oi K, Nishida H, Sasaki S, Sohara E, Rai T, Uchida S. Zeniya M, et al. Among authors: nomura n. J Am Soc Nephrol. 2015 Sep;26(9):2129-38. doi: 10.1681/ASN.2014070639. Epub 2015 Jan 2. J Am Soc Nephrol. 2015. PMID: 25556166 Free PMC article.
Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.
Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E. Yoshizaki Y, et al. Among authors: nomura n. Biochem Biophys Res Commun. 2015 Nov 13;467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3. Biochem Biophys Res Commun. 2015. PMID: 26435498
KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.
Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E. Sasaki E, et al. Among authors: nomura n. Mol Cell Biol. 2017 Mar 17;37(7):e00508-16. doi: 10.1128/MCB.00508-16. Print 2017 Apr 1. Mol Cell Biol. 2017. PMID: 28052936 Free PMC article.
Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.
Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E. Kasagi Y, et al. Among authors: nomura n. Biochem Biophys Res Commun. 2017 May 27;487(2):368-374. doi: 10.1016/j.bbrc.2017.04.068. Epub 2017 Apr 14. Biochem Biophys Res Commun. 2017. PMID: 28414128
891 results