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Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections.
Nuccitelli A, Cozzi R, Gourlay LJ, Donnarumma D, Necchi F, Norais N, Telford JL, Rappuoli R, Bolognesi M, Maione D, Grandi G, Rinaudo CD. Nuccitelli A, et al. Among authors: norais n. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10278-83. doi: 10.1073/pnas.1106590108. Epub 2011 May 18. Proc Natl Acad Sci U S A. 2011. PMID: 21593422 Free PMC article.
Sortase A substrate specificity in GBS pilus 2a cell wall anchoring.
Necchi F, Nardi-Dei V, Biagini M, Assfalg M, Nuccitelli A, Cozzi R, Norais N, Telford JL, Rinaudo CD, Grandi G, Maione D. Necchi F, et al. Among authors: norais n. PLoS One. 2011;6(10):e25300. doi: 10.1371/journal.pone.0025300. Epub 2011 Oct 4. PLoS One. 2011. PMID: 21991306 Free PMC article.
Surfome analysis as a fast track to vaccine discovery: identification of a novel protective antigen for Group B Streptococcus hypervirulent strain COH1.
Doro F, Liberatori S, Rodríguez-Ortega MJ, Rinaudo CD, Rosini R, Mora M, Scarselli M, Altindis E, D'Aurizio R, Stella M, Margarit I, Maione D, Telford JL, Norais N, Grandi G. Doro F, et al. Among authors: norais n. Mol Cell Proteomics. 2009 Jul;8(7):1728-37. doi: 10.1074/mcp.M800486-MCP200. Epub 2009 Apr 28. Mol Cell Proteomics. 2009. PMID: 19401597 Free PMC article.
The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivo.
Moschioni M, Emolo C, Biagini M, Maccari S, Pansegrau W, Donati C, Hilleringmann M, Ferlenghi I, Ruggiero P, Sinisi A, Pizza M, Norais N, Barocchi MA, Masignani V. Moschioni M, et al. Among authors: norais n. Infect Immun. 2010 Dec;78(12):5033-42. doi: 10.1128/IAI.00601-10. Epub 2010 Sep 7. Infect Immun. 2010. PMID: 20823200 Free PMC article.
Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case.
Bensi G, Mora M, Tuscano G, Biagini M, Chiarot E, Bombaci M, Capo S, Falugi F, Manetti AG, Donato P, Swennen E, Gallotta M, Garibaldi M, Pinto V, Chiappini N, Musser JM, Janulczyk R, Mariani M, Scarselli M, Telford JL, Grifantini R, Norais N, Margarit I, Grandi G. Bensi G, et al. Among authors: norais n. Mol Cell Proteomics. 2012 Jun;11(6):M111.015693. doi: 10.1074/mcp.M111.015693. Epub 2012 Jan 27. Mol Cell Proteomics. 2012. PMID: 22286755 Free PMC article.
Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome.
Rodríguez-Ortega MJ, Norais N, Bensi G, Liberatori S, Capo S, Mora M, Scarselli M, Doro F, Ferrari G, Garaguso I, Maggi T, Neumann A, Covre A, Telford JL, Grandi G. Rodríguez-Ortega MJ, et al. Among authors: norais n. Nat Biotechnol. 2006 Feb;24(2):191-7. doi: 10.1038/nbt1179. Epub 2006 Jan 15. Nat Biotechnol. 2006. PMID: 16415855
71 results