Norris JD - Search Results

1

Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

Tria GS, Abrams T, Baird J, Burks HE, Firestone B, Gaither LA, Hamann LG, He G, Kirby CA, Kim S, Lombardo F, Macchi KJ, McDonnell DP, Mishina Y, Norris JD, Nunez J, Springer C, Sun Y, Thomsen NM, Wang C, Wang J, Yu B, Tiong-Yip CL, Peukert S. Tria GS, et al. Among authors: norris jd. J Med Chem. 2018 Apr 12;61(7):2837-2864. doi: 10.1021/acs.jmedchem.7b01682. Epub 2018 Mar 22. J Med Chem. 2018. PMID: 29562737

2

Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers.

Norris J, Fan D, Aleman C, Marks JR, Futreal PA, Wiseman RW, Iglehart JD, Deininger PL, McDonnell DP. Norris J, et al. J Biol Chem. 1995 Sep 29;270(39):22777-82. doi: 10.1074/jbc.270.39.22777. J Biol Chem. 1995. PMID: 7559405 Free article.

3

BRCA1 expression is not directly responsive to estrogen.

Marks JR, Huper G, Vaughn JP, Davis PL, Norris J, McDonnell DP, Wiseman RW, Futreal PA, Iglehart JD. Marks JR, et al. Among authors: norris j. Oncogene. 1997 Jan 9;14(1):115-21. doi: 10.1038/sj.onc.1200808. Oncogene. 1997. PMID: 9010238

4

Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism.

Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S. Ramamoorthy K, et al. Among authors: norris jd. Endocrinology. 1997 Apr;138(4):1520-7. doi: 10.1210/endo.138.4.5056. Endocrinology. 1997. PMID: 9075711

5

Identification of a third autonomous activation domain within the human estrogen receptor.

Norris JD, Fan D, Kerner SA, McDonnell DP. Norris JD, et al. Mol Endocrinol. 1997 Jun;11(6):747-54. doi: 10.1210/mend.11.6.0008. Mol Endocrinol. 1997. PMID: 9171238

6

Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone.

McDonnell DP, Norris JD. McDonnell DP, et al. Among authors: norris jd. Osteoporos Int. 1997;7 Suppl 1:S29-34. doi: 10.1007/BF01674810. Osteoporos Int. 1997. PMID: 9205643 Review. No abstract available.

7

Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone.

Willson TM, Norris JD, Wagner BL, Asplin I, Baer P, Brown HR, Jones SA, Henke B, Sauls H, Wolfe S, Morris DC, McDonnell DP. Willson TM, et al. Among authors: norris jd. Endocrinology. 1997 Sep;138(9):3901-11. doi: 10.1210/endo.138.9.5358. Endocrinology. 1997. PMID: 9275080

8

The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor.

Wagner BL, Norris JD, Knotts TA, Weigel NL, McDonnell DP. Wagner BL, et al. Among authors: norris jd. Mol Cell Biol. 1998 Mar;18(3):1369-78. doi: 10.1128/MCB.18.3.1369. Mol Cell Biol. 1998. PMID: 9488452 Free PMC article.

9

Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology.

Norris JD, Fan D, Stallcup MR, McDonnell DP. Norris JD, et al. J Biol Chem. 1998 Mar 20;273(12):6679-88. doi: 10.1074/jbc.273.12.6679. J Biol Chem. 1998. PMID: 9506965 Free article.

10

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

Paige LA, Christensen DJ, Grøn H, Norris JD, Gottlin EB, Padilla KM, Chang CY, Ballas LM, Hamilton PT, McDonnell DP, Fowlkes DM. Paige LA, et al. Among authors: norris jd. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3999-4004. doi: 10.1073/pnas.96.7.3999. Proc Natl Acad Sci U S A. 1999. PMID: 10097152 Free PMC article.

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