Nuran Koçak[Author] - Search Results

Year	Number of Results
2018	1
2019	3
2020	1
2021	2
2022	2
2023	1
2024	0

1

SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function.

Gautam M, Genç B, Helmold B, Ahrens A, Kuka J, Makrecka-Kuka M, Günay A, Koçak N, Aguilar-Wickings IR, Keefe D, Zheng G, Swaminathan S, Redmon M, Zariwala HA, Özdinler PH. Gautam M, et al. Among authors: kocak n. Neurobiol Dis. 2023 Mar;178:106022. doi: 10.1016/j.nbd.2023.106022. Epub 2023 Jan 27. Neurobiol Dis. 2023. PMID: 36716828 Free article.

2

NU-9 improves health of hSOD1^G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone.

Genç B, Gautam M, Helmold BR, Koçak N, Günay A, Goshu GM, Silverman RB, Hande Ozdinler P. Genç B, et al. Among authors: kocak n. Sci Rep. 2022 Mar 30;12(1):5383. doi: 10.1038/s41598-022-09332-4. Sci Rep. 2022. PMID: 35354901 Free PMC article.

3

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons.

Genç B, Jara JH, Sanchez SS, Lagrimas AKB, Gözütok Ö, Koçak N, Zhu Y, Hande Özdinler P. Genç B, et al. Among authors: kocak n. Gene Ther. 2022 Apr;29(3-4):178-192. doi: 10.1038/s41434-021-00303-4. Epub 2021 Dec 2. Gene Ther. 2022. PMID: 34853443 Free PMC article.

4

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology.

Jara JH, Gautam M, Kocak N, Xie EF, Mao Q, Bigio EH, Özdinler PH. Jara JH, et al. Among authors: kocak n. J Neuroinflammation. 2019 Oct 30;16(1):196. doi: 10.1186/s12974-019-1589-y. J Neuroinflammation. 2019. PMID: 31666087 Free PMC article.

5

The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord.

Genc B, Gozutok O, Kocak N, Ozdinler PH. Genc B, et al. Among authors: kocak n. Cells. 2020 Feb 22;9(2):502. doi: 10.3390/cells9020502. Cells. 2020. PMID: 32098365 Free PMC article.

6

Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP-43 pathology.

Genç B, Gautam M, Gözütok Ö, Dervishi I, Sanchez S, Goshu GM, Koçak N, Xie E, Silverman RB, Özdinler PH. Genç B, et al. Among authors: kocak n. Clin Transl Med. 2021 Feb;11(2):e336. doi: 10.1002/ctm2.336. Clin Transl Med. 2021. PMID: 33634973 Free PMC article.

7

Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology.

Gautam M, Jara JH, Kocak N, Rylaarsdam LE, Kim KD, Bigio EH, Hande Özdinler P. Gautam M, et al. Among authors: kocak n. Acta Neuropathol. 2019 Jan;137(1):47-69. doi: 10.1007/s00401-018-1934-8. Epub 2018 Nov 19. Acta Neuropathol. 2019. PMID: 30450515 Free PMC article.

8

Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS.

Gautam M, Xie EF, Kocak N, Ozdinler PH. Gautam M, et al. Among authors: kocak n. Front Cell Neurosci. 2019 Nov 7;13:489. doi: 10.3389/fncel.2019.00489. eCollection 2019. Front Cell Neurosci. 2019. PMID: 31787882 Free PMC article.

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