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Guide RNA functional modules direct Cas9 activity and orthogonality.
Briner AE, Donohoue PD, Gomaa AA, Selle K, Slorach EM, Nye CH, Haurwitz RE, Beisel CL, May AP, Barrangou R. Briner AE, et al. Among authors: nye ch. Mol Cell. 2014 Oct 23;56(2):333-339. doi: 10.1016/j.molcel.2014.09.019. Epub 2014 Oct 16. Mol Cell. 2014. PMID: 25373540 Free article.
DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks.
van Overbeek M, Capurso D, Carter MM, Thompson MS, Frias E, Russ C, Reece-Hoyes JS, Nye C, Gradia S, Vidal B, Zheng J, Hoffman GR, Fuller CK, May AP. van Overbeek M, et al. Mol Cell. 2016 Aug 18;63(4):633-646. doi: 10.1016/j.molcel.2016.06.037. Epub 2016 Aug 4. Mol Cell. 2016. PMID: 27499295 Free article.