Nyrönen T - Search Results

1

BODIL: a molecular modeling environment for structure-function analysis and drug design.

Lehtonen JV, Still DJ, Rantanen VV, Ekholm J, Björklund D, Iftikhar Z, Huhtala M, Repo S, Jussila A, Jaakkola J, Pentikäinen O, Nyrönen T, Salminen T, Gyllenberg M, Johnson MS. Lehtonen JV, et al. Among authors: nyronen t. J Comput Aided Mol Des. 2004 Jun;18(6):401-19. doi: 10.1007/s10822-004-3752-4. J Comput Aided Mol Des. 2004. PMID: 15663001

2

Model structures of alpha-2 adrenoceptors in complex with automatically docked antagonist ligands raise the possibility of interactions dissimilar from agonist ligands.

Xhaard H, Nyrönen T, Rantanen VV, Ruuskanen JO, Laurila J, Salminen T, Scheinin M, Johnson MS. Xhaard H, et al. Among authors: nyronen t. J Struct Biol. 2005 May;150(2):126-43. doi: 10.1016/j.jsb.2004.12.008. J Struct Biol. 2005. PMID: 15866736

3

Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function.

Käpylä J, Pentikäinen OT, Nyrönen T, Nissinen L, Lassander S, Jokinen J, Lahti M, Marjamäki A, Johnson MS, Heino J. Käpylä J, et al. Among authors: nyronen t. J Med Chem. 2007 May 31;50(11):2742-6. doi: 10.1021/jm070063t. Epub 2007 Apr 21. J Med Chem. 2007. PMID: 17447751

4

"RKKH" peptides from the snake venom metalloproteinase of Bothrops jararaca bind near the metal ion-dependent adhesion site of the human integrin alpha(2) I-domain.

Pentikäinen O, Hoffrén AM, Ivaska J, Käpylä J, Nyrönen T, Heino J, Johnson MS. Pentikäinen O, et al. Among authors: nyronen t. J Biol Chem. 1999 Oct 29;274(44):31493-505. doi: 10.1074/jbc.274.44.31493. J Biol Chem. 1999. PMID: 10531352 Free article.

5

Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines.

Xhaard H, Rantanen VV, Nyrönen T, Johnson MS. Xhaard H, et al. Among authors: nyronen t. J Med Chem. 2006 Mar 9;49(5):1706-19. doi: 10.1021/jm0511031. J Med Chem. 2006. PMID: 16509586

6

Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine.

Nyrönen T, Pihlavisto M, Peltonen JM, Hoffrén AM, Varis M, Salminen T, Wurster S, Marjamäki A, Kanerva L, Katainen E, Laaksonen L, Savola JM, Scheinin M, Johnson MS. Nyrönen T, et al. Mol Pharmacol. 2001 May;59(5):1343-54. doi: 10.1124/mol.59.5.1343. Mol Pharmacol. 2001. PMID: 11306720

7

Determinants of antagonist binding at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D. Role of the conserved arginine 507 and glutamate 727 residues.

Jouppila A, Pentikäinen OT, Settimo L, Nyrönen T, Haapalahti JP, Lampinen M, Mottershead DG, Johnson MS, Keinänen K. Jouppila A, et al. Among authors: nyronen t. Eur J Biochem. 2002 Dec;269(24):6261-70. doi: 10.1046/j.1432-1033.2002.03345.x. Eur J Biochem. 2002. PMID: 12473122 Free article.

8

Three-dimensional models of alpha(2A)-adrenergic receptor complexes provide a structural explanation for ligand binding.

Salminen T, Varis M, Nyrönen T, Pihlavisto M, Hoffrén AM, Lönnberg T, Marjamäki A, Frang H, Savola JM, Scheinin M, Johnson MS. Salminen T, et al. Among authors: nyronen t. J Biol Chem. 1999 Aug 13;274(33):23405-13. doi: 10.1074/jbc.274.33.23405. J Biol Chem. 1999. PMID: 10438518 Free article.

9

Molecular mechanisms of ligand-receptor interactions in transmembrane domain V of the alpha2A-adrenoceptor.

Peltonen JM, Nyrönen T, Wurster S, Pihlavisto M, Hoffrén AM, Marjamäki A, Xhaard H, Kanerva L, Savola JM, Johnson MS, Scheinin M. Peltonen JM, et al. Among authors: nyronen t. Br J Pharmacol. 2003 Sep;140(2):347-58. doi: 10.1038/sj.bjp.0705439. Epub 2003 Aug 18. Br J Pharmacol. 2003. PMID: 12970108 Free PMC article.

10

A structure-activity relationship study of catechol-O-methyltransferase inhibitors combining molecular docking and 3D QSAR methods.

Tervo AJ, Nyrönen TH, Rönkkö T, Poso A. Tervo AJ, et al. Among authors: nyronen th. J Comput Aided Mol Des. 2003 Dec;17(12):797-810. doi: 10.1023/b:jcam.0000021831.47952.a7. J Comput Aided Mol Des. 2003. PMID: 15124929

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