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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1971 1
1972 2
1973 1
1975 1
2002 2
2003 1
2004 1
2005 1
2010 1
2011 1
2013 1
2018 1
2021 1
2022 2
2024 0

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19 results

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Page 1
Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O(2) Consumption of Tumour Cells.
Degitz C, Reime S, Thews O. Degitz C, et al. Among authors: thews o. Adv Exp Med Biol. 2022;1395:231-235. doi: 10.1007/978-3-031-14190-4_38. Adv Exp Med Biol. 2022. PMID: 36527642
The O(2) consumption rate (OCR) was measured at pH 7.4 and extracellular acidosis (pH 6.6) in combination with inhibition of the respective signalling pathway. ...Acidosis increased the OCR of AT1 cells, especially the basal OCR and the O(2) consumption, which is re …
The O(2) consumption rate (OCR) was measured at pH 7.4 and extracellular acidosis (pH 6.6) in combination with inhibition of the resp …
Evaluation of Betulinic Acid Derivatives as PET Tracers for Hypoxia-Induced Carbonic Anhydrase IX (CA IX) Expression.
Haupt V, Gündel D, Prell E, Kahnt M, Sommerwerk S, Riemann A, Paschke R, Csuk R, Odparlik A, Thews O. Haupt V, et al. Among authors: thews o. Adv Exp Med Biol. 2022;1395:275-280. doi: 10.1007/978-3-031-14190-4_45. Adv Exp Med Biol. 2022. PMID: 36527649
In vivo measurements were carried out in a small animal PET/CT in AT1 tumours in rats breathing room air, 8% or 100% O(2). In AT1 cells hypoxia-induced overexpression of CA IX led to a stronger binding of BS-DOTA but not of B-DOTA. ...
In vivo measurements were carried out in a small animal PET/CT in AT1 tumours in rats breathing room air, 8% or 100% O(2). In AT1 cel …
Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo.
Rauschner M, Lange L, Hüsing T, Reime S, Nolze A, Maschek M, Thews O, Riemann A. Rauschner M, et al. Among authors: thews o. J Exp Clin Cancer Res. 2021 Jan 6;40(1):10. doi: 10.1186/s13046-020-01815-4. J Exp Clin Cancer Res. 2021. PMID: 33407762 Free PMC article.
In both tumor lines acidosis induced a G1-arrest (in vivo) of the cell cycle and a strong increase in necrotic cell death (but not in apoptosis). The mitochondrial O(2) consumption increased gradually with decreasing pH. CONCLUSIONS: These data show that acidic pH(e) in tu …
In both tumor lines acidosis induced a G1-arrest (in vivo) of the cell cycle and a strong increase in necrotic cell death (but not in apopto …
Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency.
Tchirikov M, Saling E, Bapayeva G, Bucher M, Thews O, Seliger G. Tchirikov M, et al. Among authors: thews o. Physiol Rep. 2018 Mar;6(5):e13589. doi: 10.14814/phy2.13589. Physiol Rep. 2018. PMID: 29536649 Free PMC article.
In the first case, the AA and glucose were infused through a perinatal port system into the umbilical vein at 30 weeks' gestation due to severe IUGR. The patient received daily hyperbaric oxygenation (HBO, 100% O(2) ) with 1.4 atmospheres absolute for 50 min for 7 days. At …
In the first case, the AA and glucose were infused through a perinatal port system into the umbilical vein at 30 weeks' gestation due to sev …
Acidic environment leads to ROS-induced MAPK signaling in cancer cells.
Riemann A, Schneider B, Ihling A, Nowak M, Sauvant C, Thews O, Gekle M. Riemann A, et al. Among authors: thews o. PLoS One. 2011;6(7):e22445. doi: 10.1371/journal.pone.0022445. Epub 2011 Jul 26. PLoS One. 2011. PMID: 21818325 Free PMC article.
Scavenging of ROS prevented acidosis-induced MAPK phosphorylation whereas addition of H(2)O(2) enhanced it. Finally, acidosis increased phosphorylation of the transcription factor CREB via p38, leading to increased transcriptional activity of a CRE-reporter even 24 h after …
Scavenging of ROS prevented acidosis-induced MAPK phosphorylation whereas addition of H(2)O(2) enhanced it. Finally, acidosis increas …
PET imaging of the impact of extracellular pH and MAP kinases on the p-glycoprotein (Pgp) activity.
Thews O, Dillenburg W, Rösch F, Fellner M. Thews O, et al. Adv Exp Med Biol. 2013;765:279-286. doi: 10.1007/978-1-4614-4989-8_39. Adv Exp Med Biol. 2013. PMID: 22879045
When the tumors were acidified, the PET tracer accumulation was reduced by 20-30%. Changing the inspiratory O(2)-fraction to 8% led dynamically to a decrease in pH and in parallel to a reduced tracer concentration. ...
When the tumors were acidified, the PET tracer accumulation was reduced by 20-30%. Changing the inspiratory O(2)-fraction to 8% led d …
Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia.
Thews O, Wolloscheck T, Dillenburg W, Kraus S, Kelleher DK, Konerding MA, Vaupel P. Thews O, et al. Br J Cancer. 2004 Sep 13;91(6):1181-9. doi: 10.1038/sj.bjc.6602066. Br J Cancer. 2004. PMID: 15305198 Free PMC article.
In order to induce more pronounced tumour hypoxia, one group of animals was housed in a hypoxic atmosphere (8% O(2)) for the whole period of tumour growth (chronic hypoxia). ...
In order to induce more pronounced tumour hypoxia, one group of animals was housed in a hypoxic atmosphere (8% O(2)) for the whole pe …
Oxygenation status of gynecologic tumors: what is the optimal hemoglobin level?
Vaupel P, Thews O, Mayer A, Höckel S, Höckel M. Vaupel P, et al. Among authors: thews o. Strahlenther Onkol. 2002 Dec;178(12):727-31. doi: 10.1007/s00066-002-1081-x. Strahlenther Onkol. 2002. PMID: 12491062

In anemic patients (cHb < 12 g/dl), the deterioration of the tumor oxygenation status can be explained by a reduced O(2) transport capacity. At cHb values > 14 g/dl, a worsening of the tumor oxygenation is apparent, most probably due to a drop in perfusion following

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In anemic patients (cHb < 12 g/dl), the deterioration of the tumor oxygenation status can be explained by a reduced O(2) transport

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19 results