O'Connell J - Search Results

1

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.

Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, Traynor JR, Gerritz SW, Alt A. Burford NT, et al. J Med Chem. 2015 May 28;58(10):4220-9. doi: 10.1021/acs.jmedchem.5b00007. Epub 2015 May 7. J Med Chem. 2015. PMID: 25901762 Free PMC article.

2

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor.

Burford NT, Clark MJ, Wehrman TS, Gerritz SW, Banks M, O'Connell J, Traynor JR, Alt A. Burford NT, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10830-5. doi: 10.1073/pnas.1300393110. Epub 2013 Jun 10. Proc Natl Acad Sci U S A. 2013. PMID: 23754417 Free PMC article.

3

Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen.

Burford NT, Wehrman T, Bassoni D, O'Connell J, Banks M, Zhang L, Alt A. Burford NT, et al. J Biomol Screen. 2014 Oct;19(9):1255-65. doi: 10.1177/1087057114542975. Epub 2014 Jul 21. J Biomol Screen. 2014. PMID: 25047277

4

Integrating High-Content Analysis into a Multiplexed Screening Approach to Identify and Characterize GPCR Agonists.

Zhu Y, Watson J, Chen M, Shen DR, Yarde M, Agler M, Burford N, Alt A, Jayachandra S, Cvijic ME, Zhang L, Dyckman A, Xie J, O'Connell J, Banks M, Weston A. Zhu Y, et al. J Biomol Screen. 2014 Aug;19(7):1079-89. doi: 10.1177/1087057114533146. Epub 2014 Apr 30. J Biomol Screen. 2014. PMID: 24789006

5

Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.

Alt A, Pendri A, Bertekap RL Jr, Li G, Benitex Y, Nophsker M, Rockwell KL, Burford NT, Sum CS, Chen J, Herbst JJ, Ferrante M, Hendricson A, Cvijic ME, Westphal RS, O'Connell J, Banks M, Zhang L, Gentles RG, Jenkins S, Loy J, Macor JE. Alt A, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):293-304. doi: 10.1124/jpet.115.226910. Epub 2015 Nov 18. J Pharmacol Exp Ther. 2016. PMID: 26582730

6

Development of a high-throughput calcium flux assay for identification of all ligand types including positive, negative, and silent allosteric modulators for G protein-coupled receptors.

Noblin DJ, Bertekap RL Jr, Burford NT, Hendricson A, Zhang L, Knox R, Banks M, O'Connell J, Alt A. Noblin DJ, et al. Assay Drug Dev Technol. 2012 Oct;10(5):457-67. doi: 10.1089/adt.2011.443. Epub 2012 Jun 29. Assay Drug Dev Technol. 2012. PMID: 22746835

7

Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.

Sheriff S, Beno BR, Zhai W, Kostich WA, McDonnell PA, Kish K, Goldfarb V, Gao M, Kiefer SE, Yanchunas J, Huang Y, Shi S, Zhu S, Dzierba C, Bronson J, Macor JE, Appiah KK, Westphal RS, O'Connell J, Gerritz SW. Sheriff S, et al. J Med Chem. 2011 Oct 13;54(19):6548-62. doi: 10.1021/jm2003766. Epub 2011 Sep 20. J Med Chem. 2011. PMID: 21882820

8

A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors.

Appiah KK, Kostich WA, Gerritz SW, Huang Y, Hamman BD, Allen J, Zhang W, Lanthorn TH, Albright CF, Westphal R, Banks MN, O'Connell JC. Appiah KK, et al. J Biomol Screen. 2011 Jun;16(5):476-85. doi: 10.1177/1087057111399336. Epub 2011 Mar 15. J Biomol Screen. 2011. PMID: 21406618

9

Use of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay.

Zhu Z, Puglisi J, Connors D, Stewart J, Herbst J, Marino A, Sinz M, O'Connell J, Banks M, Dickinson K, Cacace A. Zhu Z, et al. J Biomol Screen. 2007 Mar;12(2):248-54. doi: 10.1177/1087057106297828. Epub 2007 Jan 26. J Biomol Screen. 2007. PMID: 17259590

10

Case study: impact of technology investment on lead discovery at Bristol-Myers Squibb, 1998-2006.

Houston JG, Banks MN, Binnie A, Brenner S, O'Connell J, Petrillo EW. Houston JG, et al. Drug Discov Today. 2008 Jan;13(1-2):44-51. doi: 10.1016/j.drudis.2007.11.004. Epub 2008 Jan 3. Drug Discov Today. 2008. PMID: 18190863 Review.

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