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Cholinergic Modulation of Disorder-Relevant Neural Circuits in Generalized Anxiety Disorder.
Wise T, Patrick F, Meyer N, Mazibuko N, Oates AE, van der Bijl AHM, Danjou P, O'Connor SM, Doolin E, Wooldridge C, Rathjen D, Macare C, Williams SCR, Perkins A, Young AH. Wise T, et al. Biol Psychiatry. 2020 May 15;87(10):908-915. doi: 10.1016/j.biopsych.2019.12.013. Epub 2020 Jan 8. Biol Psychiatry. 2020. PMID: 32107005 Free PMC article.
Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375.
Wang X, Daley C, Gakhar V, Lange HS, Vardigan JD, Pearson M, Zhou X, Warren L, Miller CO, Belden M, Harvey AJ, Grishin AA, Coles CJ, O'Connor SM, Thomson F, Duffy JL, Bell IM, Uslaner JM. Wang X, et al. J Pharmacol Exp Ther. 2020 May;373(2):311-324. doi: 10.1124/jpet.119.263483. Epub 2020 Feb 24. J Pharmacol Exp Ther. 2020. PMID: 32094294
BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents.
O'Connor SM, Sleebs BE, Street IP, Flynn BL, Baell JB, Coles C, Quazi N, Paul D, Poiraud E, Huyard B, Wagner S, Andriambeloson E, de Souza EB. O'Connor SM, et al. Neuropharmacology. 2024 Mar 15;246:109836. doi: 10.1016/j.neuropharm.2024.109836. Epub 2024 Jan 6. Neuropharmacology. 2024. PMID: 38185416 Free article.
Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs.
Harvey AJ, Avery TD, Schaeffer L, Joseph C, Huff BC, Singh R, Morice C, Giethlen B, Grishin AA, Coles CJ, Kolesik P, Wagner S, Andriambeloson E, Huyard B, Poiraud E, Paul D, O'Connor SM. Harvey AJ, et al. ACS Med Chem Lett. 2019 Mar 25;10(5):754-760. doi: 10.1021/acsmedchemlett.9b00001. eCollection 2019 May 9. ACS Med Chem Lett. 2019. PMID: 31097995 Free PMC article.
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.
Beinat C, Reekie T, Banister SD, O'Brien-Brown J, Xie T, Olson TT, Xiao Y, Harvey A, O'Connor S, Coles C, Grishin A, Kolesik P, Tsanaktsidis J, Kassiou M. Beinat C, et al. Eur J Med Chem. 2015 May 5;95:277-301. doi: 10.1016/j.ejmech.2015.03.025. Epub 2015 Mar 14. Eur J Med Chem. 2015. PMID: 25827398
129 results