O'Hagan HM - Search Results

1

Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer.

Ghobashi AH, Vuong TT, Kimani JW, O'Hagan HM. Ghobashi AH, et al. Among authors: o hagan hm. bioRxiv [Preprint]. 2023 Feb 4:2023.01.31.526429. doi: 10.1101/2023.01.31.526429. bioRxiv. 2023. PMID: 36778289 Free PMC article. Updated. Preprint.

2

Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer.

Sriramkumar S, Matthews TD, Ghobashi AH, Miller SA, VanderVere-Carozza PS, Pawelczak KS, Nephew KP, Turchi JJ, O'Hagan HM. Sriramkumar S, et al. Mol Cancer Res. 2020 Nov;18(11):1699-1710. doi: 10.1158/1541-7786.MCR-20-0396. Epub 2020 Aug 14. Mol Cancer Res. 2020. PMID: 32801161 Free PMC article.

3

Consensus molecular subtyping of colorectal cancers is influenced by goblet cell content.

Miller SA, Ghobashi AH, O'Hagan HM. Miller SA, et al. Cancer Genet. 2021 Jun;254-255:34-39. doi: 10.1016/j.cancergen.2021.01.009. Epub 2021 Jan 26. Cancer Genet. 2021. PMID: 33571895

4

Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer.

Sriramkumar S, Sood R, Huntington TD, Ghobashi AH, Vuong TT, Metcalfe TX, Wang W, Nephew KP, O'Hagan HM. Sriramkumar S, et al. Among authors: o hagan hm. J Transl Med. 2022 May 31;20(1):246. doi: 10.1186/s12967-022-03447-y. J Transl Med. 2022. PMID: 35641987 Free PMC article.

5

Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer.

Ghobashi AH, Vuong TT, Kimani JW, Ladaika CA, Hollenhorst PC, O'Hagan HM. Ghobashi AH, et al. Among authors: o hagan hm. iScience. 2023 Aug 16;26(9):107630. doi: 10.1016/j.isci.2023.107630. eCollection 2023 Sep 15. iScience. 2023. PMID: 37670785 Free PMC article.

6

Single-cell profiling reveals the impact of genetic alterations on the differentiation of inflammation-induced colon tumors.

Ghobashi AH, Lanzloth R, Ladaika CA, O'Hagan HM. Ghobashi AH, et al. Among authors: o hagan hm. bioRxiv [Preprint]. 2023 Dec 2:2023.11.30.569463. doi: 10.1101/2023.11.30.569463. bioRxiv. 2023. PMID: 38077052 Free PMC article. Preprint.

7

Single-cell multi-omics reveals insights into differentiation of rare cell types in mucinous colorectal cancer.

Ladaika CA, Ghobashi AH, Boulton WC, Miller SA, O'Hagan HM. Ladaika CA, et al. Among authors: o hagan hm. bioRxiv [Preprint]. 2024 Feb 5:2024.02.01.578409. doi: 10.1101/2024.02.01.578409. bioRxiv. 2024. PMID: 38370733 Free PMC article. Preprint.

8

Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer.

Miller SA, Policastro RA, Savant SS, Sriramkumar S, Ding N, Lu X, Mohammad HP, Cao S, Kalin JH, Cole PA, Zentner GE, O'Hagan HM. Miller SA, et al. Mol Cancer Res. 2020 Feb;18(2):264-277. doi: 10.1158/1541-7786.MCR-19-0748. Epub 2019 Nov 8. Mol Cancer Res. 2020. PMID: 31704733 Free PMC article.

9

LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support BRAF-Mutant Colorectal Cancer.

Miller SA, Policastro RA, Sriramkumar S, Lai T, Huntington TD, Ladaika CA, Kim D, Hao C, Zentner GE, O'Hagan HM. Miller SA, et al. Among authors: o hagan hm. Cancer Res. 2021 Jul 15;81(14):3791-3805. doi: 10.1158/0008-5472.CAN-20-3562. Epub 2021 May 25. Cancer Res. 2021. PMID: 34035083 Free PMC article.

10

Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.

Chitre S, Ray AM, Stevens M, Doud EH, Liechty H, Washburn A, Tepper K, Sivinski J, O'Hagan HM, Georgiadis MM, Chapman E, Johnson SM. Chitre S, et al. Among authors: o hagan hm. Bioorg Med Chem. 2022 Dec 1;75:117072. doi: 10.1016/j.bmc.2022.117072. Epub 2022 Oct 30. Bioorg Med Chem. 2022. PMID: 36356534

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