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PERM1 regulates energy metabolism in the heart via ERRα/PGC-1α axis.
Oka SI, Sreedevi K, Shankar TS, Yedla S, Arowa S, James A, Stone KG, Olmos K, Sabry AD, Horiuchi A, Cawley KM, O'very SA, Tong M, Byun J, Xu X, Kashyap S, Mourad Y, Vehra O, Calder D, Lunde T, Liu T, Li H, Mashchek JA, Cox J, Saijoh Y, Drakos SG, Warren JS. Oka SI, et al. Among authors: o very sa. Front Cardiovasc Med. 2022 Nov 7;9:1033457. doi: 10.3389/fcvm.2022.1033457. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36419485 Free PMC article.
Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.
Oka SI, Sabry AD, Horiuchi AK, Cawley KM, O'Very SA, Zaitsev MA, Shankar TS, Byun J, Mukai R, Xu X, Torres NS, Kumar A, Yazawa M, Ling J, Taleb I, Saijoh Y, Drakos SG, Sadoshima J, Warren JS. Oka SI, et al. Among authors: o very sa. PLoS One. 2020 Jun 23;15(6):e0234913. doi: 10.1371/journal.pone.0234913. eCollection 2020. PLoS One. 2020. PMID: 32574189 Free PMC article.
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.
Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O'Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S. Szulik MW, et al. Basic Res Cardiol. 2023 May 22;118(1):20. doi: 10.1007/s00395-023-00991-6. Basic Res Cardiol. 2023. PMID: 37212935 Free PMC article.