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G-quadruplexes associated with R-loops promote CTCF binding.
Wulfridge P, Yan Q, Rell N, Doherty J, Jacobson S, Offley S, Deliard S, Feng K, Phillips-Cremins JE, Gardini A, Sarma K. Wulfridge P, et al. Among authors: offley s. Mol Cell. 2023 Sep 7;83(17):3064-3079.e5. doi: 10.1016/j.molcel.2023.07.009. Epub 2023 Aug 7. Mol Cell. 2023. PMID: 37552993
A combinatorial approach to uncover an additional Integrator subunit.
Offley SR, Pfleiderer MM, Zucco A, Fraudeau A, Welsh SA, Razew M, Galej WP, Gardini A. Offley SR, et al. Cell Rep. 2023 Mar 28;42(3):112244. doi: 10.1016/j.celrep.2023.112244. Epub 2023 Mar 14. Cell Rep. 2023. PMID: 36920904 Free PMC article.
Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders.
Pagliaroli L, Porazzi P, Curtis AT, Scopa C, Mikkers HMM, Freund C, Daxinger L, Deliard S, Welsh SA, Offley S, Ott CA, Calabretta B, Brugmann SA, Santen GWE, Trizzino M. Pagliaroli L, et al. Among authors: offley s. Nat Commun. 2021 Nov 9;12(1):6469. doi: 10.1038/s41467-021-26810-x. Nat Commun. 2021. PMID: 34753942 Free PMC article.
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Vervoort SJ, Welsh SA, Devlin JR, Barbieri E, Knight DA, Offley S, Bjelosevic S, Costacurta M, Todorovski I, Kearney CJ, Sandow JJ, Fan Z, Blyth B, McLeod V, Vissers JHA, Pavic K, Martin BP, Gregory G, Demosthenous E, Zethoven M, Kong IY, Hawkins ED, Hogg SJ, Kelly MJ, Newbold A, Simpson KJ, Kauko O, Harvey KF, Ohlmeyer M, Westermarck J, Gray N, Gardini A, Johnstone RW. Vervoort SJ, et al. Among authors: offley s. Cell. 2021 Jun 10;184(12):3143-3162.e32. doi: 10.1016/j.cell.2021.04.022. Epub 2021 May 17. Cell. 2021. PMID: 34004147 Free PMC article.
Protein phosphatases of Saccharomyces cerevisiae.
Offley SR, Schmidt MC. Offley SR, et al. Curr Genet. 2019 Feb;65(1):41-55. doi: 10.1007/s00294-018-0884-y. Epub 2018 Sep 17. Curr Genet. 2019. PMID: 30225534 Free PMC article. Review.
Murine model of oligotrophic tibial nonunion.
Hu CT, Offley SC, Yaseen Z, O'Keefe RJ, Humphrey CA. Hu CT, et al. Among authors: offley sc. J Orthop Trauma. 2011 Aug;25(8):500-5. doi: 10.1097/BOT.0b013e3182249fad. J Orthop Trauma. 2011. PMID: 21738067
Investigation of the peak action wavelength of light-activated gene transduction.
Myakishev-Rempel M, Kuper J, Mintz B, Hutchinson S, Voris J, Zavislan K, Offley S, Nardia FB, Yaseen Z, Yen T, Zavislan JM, Maloney MD, Schwarz EM. Myakishev-Rempel M, et al. Among authors: offley s. Gene Ther. 2011 Nov;18(11):1043-51. doi: 10.1038/gt.2011.47. Epub 2011 Apr 14. Gene Ther. 2011. PMID: 21490685 Free PMC article.
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