Ohtsuka T - Search Results

1

Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

Ichikawa K, Liu W, Zhao L, Wang Z, Liu D, Ohtsuka T, Zhang H, Mountz JD, Koopman WJ, Kimberly RP, Zhou T. Ichikawa K, et al. Among authors: ohtsuka t. Nat Med. 2001 Aug;7(8):954-60. doi: 10.1038/91000. Nat Med. 2001. PMID: 11479629

2

Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways.

Ohtsuka T, Zhou T. Ohtsuka T, et al. J Biol Chem. 2002 Aug 9;277(32):29294-303. doi: 10.1074/jbc.M203342200. Epub 2002 May 28. J Biol Chem. 2002. PMID: 12034736 Free article.

3

Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway.

Ohtsuka T, Buchsbaum D, Oliver P, Makhija S, Kimberly R, Zhou T. Ohtsuka T, et al. Oncogene. 2003 Apr 3;22(13):2034-44. doi: 10.1038/sj.onc.1206290. Oncogene. 2003. PMID: 12673208

4

Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL.

Kawaida R, Ohtsuka T, Okutsu J, Takahashi T, Kadono Y, Oda H, Hikita A, Nakamura K, Tanaka S, Furukawa H. Kawaida R, et al. Among authors: ohtsuka t. J Exp Med. 2003 Apr 21;197(8):1029-35. doi: 10.1084/jem.20021321. J Exp Med. 2003. PMID: 12707301 Free PMC article.

5

TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis.

Ichikawa K, Liu W, Fleck M, Zhang H, Zhao L, Ohtsuka T, Wang Z, Liu D, Mountz JD, Ohtsuki M, Koopman WJ, Kimberly R, Zhou T. Ichikawa K, et al. Among authors: ohtsuka t. J Immunol. 2003 Jul 15;171(2):1061-9. doi: 10.4049/jimmunol.171.2.1061. J Immunol. 2003. PMID: 12847280

6

Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon.

Kubota K, Nakahara K, Ohtsuka T, Yoshida S, Kawaguchi J, Fujita Y, Ozeki Y, Hara A, Yoshimura C, Furukawa H, Haruyama H, Ichikawa K, Yamashita M, Matsuoka T, Iijima Y. Kubota K, et al. Among authors: ohtsuka t. J Biol Chem. 2004 Sep 3;279(36):37832-41. doi: 10.1074/jbc.M400089200. Epub 2004 Jun 30. J Biol Chem. 2004. PMID: 15231837 Free article.

7

In Vitro and In Vivo Evaluation of ⁸⁹Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy.

Burvenich IJ, Lee FT, Guo N, Gan HK, Rigopoulos A, Parslow AC, O'Keefe GJ, Gong SJ, Tochon-Danguy H, Rudd SE, Donnelly PS, Kotsuma M, Ohtsuka T, Senaldi G, Scott AM. Burvenich IJ, et al. Among authors: ohtsuka t. Theranostics. 2016 Sep 25;6(12):2225-2234. doi: 10.7150/thno.16260. eCollection 2016. Theranostics. 2016. PMID: 27924159 Free PMC article.

8

Ongoing myocardial damage in chronic heart failure is related to activated tumor necrosis factor and Fas/Fas ligand system.

Setsuta K, Seino Y, Ogawa T, Ohtsuka T, Seimiya K, Takano T. Setsuta K, et al. Among authors: ohtsuka t. Circ J. 2004 Aug;68(8):747-50. doi: 10.1253/circj.68.747. Circ J. 2004. PMID: 15277733 Free article.

9

Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity.

Bartz R, Fukuchi K, Ohtsuka T, Lange T, Gruner K, Watanabe I, Hayashi S, Oda Y, Kawaida R, Komori H, Kashimoto Y, Wirtz P, Mayer JA, Redondo-Müller M, Saito S, Takahashi M, Hanzawa H, Imai E, Martinez A, Hanai M, Häussinger D, Chapman RW, Agatsuma T, Bange J, Abraham R. Bartz R, et al. Among authors: ohtsuka t. Mol Cancer Ther. 2019 Oct;18(10):1832-1843. doi: 10.1158/1535-7163.MCT-18-0048. Epub 2019 Jul 26. Mol Cancer Ther. 2019. PMID: 31350344

10

Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals.

Fukuchi K, Nanai K, Yuita H, Maru C, Tsukada J, Ishigami M, Nagai Y, Nakano Y, Yoshimura C, Yoneda K, Amano M, Nakamura K, Oda Y, Nishigohri H, Yamamoto S, Ohnishi-Totoki Y, Inaki K, Komori H, Nakano R, Kanari Y, Nishida A, Matsui Y, Funo S, Takahashi S, Ohtsuka T, Agatsuma T. Fukuchi K, et al. Among authors: ohtsuka t. J Oncol. 2022 Nov 4;2022:3552793. doi: 10.1155/2022/3552793. eCollection 2022. J Oncol. 2022. PMID: 36385956 Free PMC article.

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