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DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. Mao C, et al. Among authors: olszewski k. Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12. Nature. 2021. PMID: 33981038 Free PMC article.
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.
Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Liu X, et al. Among authors: olszewski k. Nat Cell Biol. 2020 Apr;22(4):476-486. doi: 10.1038/s41556-020-0496-x. Epub 2020 Mar 30. Nat Cell Biol. 2020. PMID: 32231310 Free PMC article.
Thiol profiling in cancer cell lines by HPLC-mass spectrometry.
Liu X, Koppula P, Olszewski K, Gan B. Liu X, et al. Among authors: olszewski k. STAR Protoc. 2021 Dec 8;2(4):100977. doi: 10.1016/j.xpro.2021.100977. eCollection 2021 Dec 17. STAR Protoc. 2021. PMID: 34917974 Free PMC article.
Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors.
Olszewski K, Barsotti A, Feng XJ, Momcilovic M, Liu KG, Kim JI, Morris K, Lamarque C, Gaffney J, Yu X, Patel JP, Rabinowitz JD, Shackelford DB, Poyurovsky MV. Olszewski K, et al. Cell Chem Biol. 2022 Mar 17;29(3):423-435.e10. doi: 10.1016/j.chembiol.2021.10.007. Epub 2021 Oct 28. Cell Chem Biol. 2022. PMID: 34715056 Free article.
Discovery and Optimization of Glucose Uptake Inhibitors.
Liu KG, Kim JI, Olszewski K, Barsotti AM, Morris K, Lamarque C, Yu X, Gaffney J, Feng XJ, Patel JP, Poyurovsky MV. Liu KG, et al. Among authors: olszewski k. J Med Chem. 2020 May 28;63(10):5201-5211. doi: 10.1021/acs.jmedchem.9b02153. Epub 2020 May 8. J Med Chem. 2020. PMID: 32282207
139 results