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Glycerol, a possible new player in the biology of trypanosomes.
Bringaud F, Plazolles N, Pineda E, Asencio C, Villafraz O, Millerioux Y, Rivière L, Tetaud E. Bringaud F, et al. Among authors: villafraz o. PLoS Pathog. 2021 Dec 2;17(12):e1010035. doi: 10.1371/journal.ppat.1010035. eCollection 2021 Dec. PLoS Pathog. 2021. PMID: 34855923 Free PMC article. No abstract available.
Glycerol suppresses glucose consumption in trypanosomes through metabolic contest.
Allmann S, Wargnies M, Plazolles N, Cahoreau E, Biran M, Morand P, Pineda E, Kulyk H, Asencio C, Villafraz O, Rivière L, Tetaud E, Rotureau B, Mourier A, Portais JC, Bringaud F. Allmann S, et al. Among authors: villafraz o. PLoS Biol. 2021 Aug 13;19(8):e3001359. doi: 10.1371/journal.pbio.3001359. eCollection 2021 Aug. PLoS Biol. 2021. PMID: 34388147 Free PMC article.
Gluconeogenesis is essential for trypanosome development in the tsetse fly vector.
Wargnies M, Bertiaux E, Cahoreau E, Ziebart N, Crouzols A, Morand P, Biran M, Allmann S, Hubert J, Villafraz O, Millerioux Y, Plazolles N, Asencio C, Rivière L, Rotureau B, Boshart M, Portais JC, Bringaud F. Wargnies M, et al. Among authors: villafraz o. PLoS Pathog. 2018 Dec 17;14(12):e1007502. doi: 10.1371/journal.ppat.1007502. eCollection 2018 Dec. PLoS Pathog. 2018. PMID: 30557412 Free PMC article.
Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase.
Wargnies M, Plazolles N, Schenk R, Villafraz O, Dupuy JW, Biran M, Bachmaier S, Baudouin H, Clayton C, Boshart M, Bringaud F. Wargnies M, et al. Among authors: villafraz o. J Biol Chem. 2021 Jan-Jun;296:100548. doi: 10.1016/j.jbc.2021.100548. Epub 2021 Mar 17. J Biol Chem. 2021. PMID: 33741344 Free PMC article.
Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline.
Villafraz O, Biran M, Pineda E, Plazolles N, Cahoreau E, Ornitz Oliveira Souza R, Thonnus M, Allmann S, Tetaud E, Rivière L, Silber AM, Barrett MP, Zíková A, Boshart M, Portais JC, Bringaud F. Villafraz O, et al. PLoS Pathog. 2021 Mar 1;17(3):e1009204. doi: 10.1371/journal.ppat.1009204. eCollection 2021 Mar. PLoS Pathog. 2021. PMID: 33647053 Free PMC article.