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Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
Lu X, Sabbasani VR, Osei-Amponsa V, Evans CN, King JC, Tarasov SG, Dyba M, Das S, Chan KC, Schwieters CD, Choudhari S, Fromont C, Zhao Y, Tran B, Chen X, Matsuo H, Andresson T, Chari R, Swenson RE, Tarasova NI, Walters KJ. Lu X, et al. Among authors: osei amponsa v. Nat Commun. 2021 Dec 16;12(1):7318. doi: 10.1038/s41467-021-27570-4. Nat Commun. 2021. PMID: 34916494 Free PMC article.
An engineered cell line with a hRpn1-attached handle to isolate proteasomes.
Negi H, Osei-Amponsa V, Ibrahim B, Evans CN, Sullenberger C, Loncarek J, Chari R, Walters KJ. Negi H, et al. Among authors: osei amponsa v. J Biol Chem. 2023 Aug;299(8):104948. doi: 10.1016/j.jbc.2023.104948. Epub 2023 Jun 22. J Biol Chem. 2023. PMID: 37354974 Free PMC article.
Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer.
Osei-Amponsa V, Buckwalter JM, Shuman L, Zheng Z, Yamashita H, Walter V, Wildermuth T, Ellis-Mohl J, Liu C, Warrick JI, Shantz LM, Feehan RP, Al-Ahmadie H, Mendelsohn C, Raman JD, Kaestner KH, Wu XR, DeGraff DJ. Osei-Amponsa V, et al. Oncogene. 2020 Feb;39(6):1302-1317. doi: 10.1038/s41388-019-1063-4. Epub 2019 Oct 21. Oncogene. 2020. PMID: 31636388