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Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
Nat Commun. 2021 Dec 16;12(1):7318. doi: 10.1038/s41467-021-27570-4.
Nat Commun. 2021.
PMID: 34916494
Free PMC article.
Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity.
Osei-Amponsa V, Sridharan V, Tandon M, Evans CN, Klarmann K, Cheng KT, Lack J, Chari R, Walters KJ.
Osei-Amponsa V, et al.
Mol Cell Biol. 2020 Aug 28;40(18):e00122-20. doi: 10.1128/MCB.00122-20. Print 2020 Aug 28.
Mol Cell Biol. 2020.
PMID: 32631902
Free PMC article.
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Proteasome substrate receptors and their therapeutic potential.
Osei-Amponsa V, Walters KJ.
Osei-Amponsa V, et al.
Trends Biochem Sci. 2022 Nov;47(11):950-964. doi: 10.1016/j.tibs.2022.06.006. Epub 2022 Jul 9.
Trends Biochem Sci. 2022.
PMID: 35817651
Free PMC article.
Review.
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Protocol for cytoskeleton staining of the semi-adherent multiple myeloma cell line RPMI 8226 by immunofluorescence.
Osei-Amponsa V, Magidson V, Walters KJ.
Osei-Amponsa V, et al.
STAR Protoc. 2024 May 2;5(2):103060. doi: 10.1016/j.xpro.2024.103060. Online ahead of print.
STAR Protoc. 2024.
PMID: 38700979
Free article.
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hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.
Osei-Amponsa V, Chandravanshi M, Lu X, Magidson V, Das S, Andresson T, Dyba M, Sabbasani VR, Swenson RE, Fromont C, Shrestha B, Zhao Y, Clapp ME, Chari R, Walters KJ.
Osei-Amponsa V, et al.
Mol Cell. 2024 Feb 1;84(3):522-537.e8. doi: 10.1016/j.molcel.2023.11.035. Epub 2023 Dec 26.
Mol Cell. 2024.
PMID: 38151017
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An engineered cell line with a hRpn1-attached handle to isolate proteasomes.
Negi H, Osei-Amponsa V, Ibrahim B, Evans CN, Sullenberger C, Loncarek J, Chari R, Walters KJ.
Negi H, et al. Among authors: osei amponsa v.
J Biol Chem. 2023 Aug;299(8):104948. doi: 10.1016/j.jbc.2023.104948. Epub 2023 Jun 22.
J Biol Chem. 2023.
PMID: 37354974
Free PMC article.
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Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer.
Osei-Amponsa V, Buckwalter JM, Shuman L, Zheng Z, Yamashita H, Walter V, Wildermuth T, Ellis-Mohl J, Liu C, Warrick JI, Shantz LM, Feehan RP, Al-Ahmadie H, Mendelsohn C, Raman JD, Kaestner KH, Wu XR, DeGraff DJ.
Osei-Amponsa V, et al.
Oncogene. 2020 Feb;39(6):1302-1317. doi: 10.1038/s41388-019-1063-4. Epub 2019 Oct 21.
Oncogene. 2020.
PMID: 31636388
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