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Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.
Robinson MJ, Osheroff N. Robinson MJ, et al. Among authors: osheroff n. Biochemistry. 1991 Feb 19;30(7):1807-13. doi: 10.1021/bi00221a012. Biochemistry. 1991. PMID: 1847075
Since previous studies demonstrated that antineoplastic drugs stabilize the pre-strand-passage cleavage complex of topoisomerase II by impairing the enzyme's ability to religate cleaved DNA [Osheroff, N. (1989) Biochemistry 28, 6157-6160; Robinson, M.J., & Os …
Since previous studies demonstrated that antineoplastic drugs stabilize the pre-strand-passage cleavage complex of topoisomerase II by impai …
Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.
Robinson MJ, Osheroff N. Robinson MJ, et al. Among authors: osheroff n. Biochemistry. 1990 Mar 13;29(10):2511-5. doi: 10.1021/bi00462a012. Biochemistry. 1990. PMID: 2159323
This result is similar to that previously reported for the effects of etoposide on the activity of the Drosophila enzyme [Osheroff, N. (1989) Biochemistry 28, 6157-6160]. Thus, it appears that structurally disparate classes of topoisomerase II targeted antineoplasti …
This result is similar to that previously reported for the effects of etoposide on the activity of the Drosophila enzyme [Osheroff, …
Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.
Osheroff N. Osheroff N. Biochemistry. 1989 Jul 25;28(15):6157-60. doi: 10.1021/bi00441a005. Biochemistry. 1989. PMID: 2551366
By employing a topoisomerase II mediated DNA religation assay [Osheroff, N. & Zechiedrich, E.L. (1987) Biochemistry 26, 4303-4309], etoposide was found to stabilize the enzyme-DNA cleavage complex (at least in part) by inhibiting the enzyme's ability to religate …
By employing a topoisomerase II mediated DNA religation assay [Osheroff, N. & Zechiedrich, E.L. (1987) Biochemistry 26, 43 …
Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate.
Zechiedrich EL, Christiansen K, Andersen AH, Westergaard O, Osheroff N. Zechiedrich EL, et al. Among authors: osheroff n. Biochemistry. 1989 Jul 25;28(15):6229-36. doi: 10.1021/bi00441a014. Biochemistry. 1989. PMID: 2551367
These experiments revealed that separate polypeptide chains were complexed with both ends of linear DNA molecules generated during cleavage reactions. Finally, by use of a novel religation assay [Osheroff, N., & Zechiedrich, E. L. (1987) Biochemistry 26, 4303-43 …
These experiments revealed that separate polypeptide chains were complexed with both ends of linear DNA molecules generated during cleavage …
242 results