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Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M. Kazuki Y, et al. Among authors: oshimura m. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3072-3081. doi: 10.1073/pnas.1808255116. Epub 2019 Feb 4. Proc Natl Acad Sci U S A. 2019. PMID: 30718425 Free PMC article.
Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.
Kazuki Y, Kobayashi K, Aueviriyavit S, Oshima T, Kuroiwa Y, Tsukazaki Y, Senda N, Kawakami H, Ohtsuki S, Abe S, Takiguchi M, Hoshiya H, Kajitani N, Takehara S, Kubo K, Terasaki T, Chiba K, Tomizuka K, Oshimura M. Kazuki Y, et al. Among authors: oshimura m. Hum Mol Genet. 2013 Feb 1;22(3):578-92. doi: 10.1093/hmg/dds468. Epub 2012 Nov 2. Hum Mol Genet. 2013. PMID: 23125282
Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.
Kazuki Y, Akita M, Kobayashi K, Osaki M, Satoh D, Ohta R, Abe S, Takehara S, Kazuki K, Yamazaki H, Kamataki T, Oshimura M. Kazuki Y, et al. Among authors: oshimura m. Sci Rep. 2016 Feb 23;6:21419. doi: 10.1038/srep21419. Sci Rep. 2016. PMID: 26903378 Free PMC article.
Transchromosomic technology for genomically humanized animals.
Moriwaki T, Abe S, Oshimura M, Kazuki Y. Moriwaki T, et al. Among authors: oshimura m. Exp Cell Res. 2020 May 15;390(2):111914. doi: 10.1016/j.yexcr.2020.111914. Epub 2020 Mar 3. Exp Cell Res. 2020. PMID: 32142854 Free article. Review.
509 results