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Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.
Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL. Patel R, et al. Among authors: owen bm. Mol Endocrinol. 2015 Feb;29(2):213-23. doi: 10.1210/me.2014-1259. Epub 2014 Dec 11. Mol Endocrinol. 2015. PMID: 25495872 Free PMC article.
FGF21 Regulates Sweet and Alcohol Preference.
Talukdar S, Owen BM, Song P, Hernandez G, Zhang Y, Zhou Y, Scott WT, Paratala B, Turner T, Smith A, Bernardo B, Müller CP, Tang H, Mangelsdorf DJ, Goodwin B, Kliewer SA. Talukdar S, et al. Among authors: owen bm. Cell Metab. 2016 Feb 9;23(2):344-9. doi: 10.1016/j.cmet.2015.12.008. Epub 2015 Dec 24. Cell Metab. 2016. PMID: 26724861 Free PMC article.
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.
Talukdar S, Zhou Y, Li D, Rossulek M, Dong J, Somayaji V, Weng Y, Clark R, Lanba A, Owen BM, Brenner MB, Trimmer JK, Gropp KE, Chabot JR, Erion DM, Rolph TP, Goodwin B, Calle RA. Talukdar S, et al. Among authors: owen bm. Cell Metab. 2016 Mar 8;23(3):427-40. doi: 10.1016/j.cmet.2016.02.001. Cell Metab. 2016. PMID: 26959184 Free article. Clinical Trial.
41 results