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Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.
Brouwer PJM, Brinkkemper M, Maisonnasse P, Dereuddre-Bosquet N, Grobben M, Claireaux M, de Gast M, Marlin R, Chesnais V, Diry S, Allen JD, Watanabe Y, Giezen JM, Kerster G, Turner HL, van der Straten K, van der Linden CA, Aldon Y, Naninck T, Bontjer I, Burger JA, Poniman M, Mykytyn AZ, Okba NMA, Schermer EE, van Breemen MJ, Ravichandran R, Caniels TG, van Schooten J, Kahlaoui N, Contreras V, Lemaître J, Chapon C, Fang RHT, Villaudy J, Sliepen K, van der Velden YU, Haagmans BL, de Bree GJ, Ginoux E, Ward AB, Crispin M, King NP, van der Werf S, van Gils MJ, Le Grand R, Sanders RW. Brouwer PJM, et al. Among authors: maisonnasse p. Cell. 2021 Mar 4;184(5):1188-1200.e19. doi: 10.1016/j.cell.2021.01.035. Epub 2021 Jan 26. Cell. 2021. PMID: 33577765 Free PMC article.
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models.
Maisonnasse P, Aldon Y, Marc A, Marlin R, Dereuddre-Bosquet N, Kuzmina NA, Freyn AW, Snitselaar JL, Gonçalves A, Caniels TG, Burger JA, Poniman M, Bontjer I, Chesnais V, Diry S, Iershov A, Ronk AJ, Jangra S, Rathnasinghe R, Brouwer PJM, Bijl TPL, van Schooten J, Brinkkemper M, Liu H, Yuan M, Mire CE, van Breemen MJ, Contreras V, Naninck T, Lemaître J, Kahlaoui N, Relouzat F, Chapon C, Ho Tsong Fang R, McDanal C, Osei-Twum M, St-Amant N, Gagnon L, Montefiori DC, Wilson IA, Ginoux E, de Bree GJ, García-Sastre A, Schotsaert M, Coughlan L, Bukreyev A, van der Werf S, Guedj J, Sanders RW, van Gils MJ, Le Grand R. Maisonnasse P, et al. Nat Commun. 2021 Oct 20;12(1):6097. doi: 10.1038/s41467-021-26354-0. Nat Commun. 2021. PMID: 34671037 Free PMC article.
Innate cell markers that predict anti-HIV neutralizing antibody titers in vaccinated macaques.
Van Tilbeurgh M, Maisonnasse P, Palgen JL, Tolazzi M, Aldon Y, Dereuddre-Bosquet N, Cavarelli M, Beignon AS, Marcos-Lopez E, Gallouet AS, Gilson E, Ozorowski G, Ward AB, Bontjer I, McKay PF, Shattock RJ, Scarlatti G, Sanders RW, Le Grand R. Van Tilbeurgh M, et al. Among authors: maisonnasse p. Cell Rep Med. 2022 Oct 18;3(10):100751. doi: 10.1016/j.xcrm.2022.100751. Epub 2022 Sep 26. Cell Rep Med. 2022. PMID: 36167072 Free PMC article.

Various combinations of these markers characterize cell families positively associated with nAb production, whereas CADM1-expressing cells are negatively associated (p < 0.05). Our results demonstrate that monitoring immune signatures during early vaccine development co

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Various combinations of these markers characterize cell families positively associated with nAb production, whereas CADM1-expressing cells a …
A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern.
Brinkkemper M, Brouwer PJM, Maisonnasse P, Grobben M, Caniels TG, Poniman M, Burger JA, Bontjer I, Oomen M, Bouhuijs JH, van der Linden CA, Villaudy J, van der Velden YU, Sliepen K, van Gils MJ, Le Grand R, Sanders RW. Brinkkemper M, et al. Among authors: maisonnasse p. NPJ Vaccines. 2021 Dec 3;6(1):146. doi: 10.1038/s41541-021-00411-7. NPJ Vaccines. 2021. PMID: 34862406 Free PMC article.
Our data show that a third immunization improves neutralizing antibody titers against the variants-of-concern, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2). After three vaccinations, the level of neutralization against Beta was similar to the level o …
Our data show that a third immunization improves neutralizing antibody titers against the variants-of-concern, Alpha (B.1.1.7), Beta (B.1.35 …
Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients.
Funnell SGP, Dowling WE, Muñoz-Fontela C, Gsell PS, Ingber DE, Hamilton GA, Delang L, Rocha-Pereira J, Kaptein S, Dallmeier KH, Neyts J, Rosenke K, de Wit E, Feldmann H, Maisonnasse P, Le Grand R, Frieman MB, Coleman CM. Funnell SGP, et al. Among authors: maisonnasse p. Nat Commun. 2020 Aug 26;11(1):4253. doi: 10.1038/s41467-020-17907-w. Nat Commun. 2020. PMID: 32848158 Free PMC article.
Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates.
Marc A, Marlin R, Donati F, Prague M, Kerioui M, Hérate C, Alexandre M, Dereuddre-Bosquet N, Bertrand J, Contreras V, Behillil S, Maisonnasse P, Van Der Werf S, Le Grand R, Guedj J. Marc A, et al. Among authors: maisonnasse p. PLoS Comput Biol. 2023 Aug 9;19(8):e1010721. doi: 10.1371/journal.pcbi.1010721. eCollection 2023 Aug. PLoS Comput Biol. 2023. PMID: 37556476 Free PMC article.
When compared with the historical variant, all VoC except beta were associated with an escape from this immune response, and this effect was particularly sensitive for delta and omicron variant (p<10-6 for both). Interestingly, delta variant was associated with a 1.8-fo …
When compared with the historical variant, all VoC except beta were associated with an escape from this immune response, and this effect was …
Combined neonicotinoid pesticide and parasite stress alter honeybee queens' physiology and survival.
Dussaubat C, Maisonnasse A, Crauser D, Tchamitchian S, Bonnet M, Cousin M, Kretzschmar A, Brunet JL, Le Conte Y. Dussaubat C, et al. Among authors: maisonnasse a. Sci Rep. 2016 Aug 31;6:31430. doi: 10.1038/srep31430. Sci Rep. 2016. PMID: 27578396 Free PMC article.
Stressors also alter the activity of two other enzymes (carboxylesterase alpha [CaE alpha] and carboxylesterase para [CaE p] in the midguts) involved in metabolic and detoxification functions. ...
Stressors also alter the activity of two other enzymes (carboxylesterase alpha [CaE alpha] and carboxylesterase para [CaE p] in the m …
Validation of the Performance of A1HPV6, a Triage Blood Test for the Early Diagnosis and Prognosis of SARS-CoV-2 Infection.
Maisonnasse P, Poynard T, Sakka M, Akhavan S, Marlin R, Peta V, Deckmyn O, Ghedira NB, Ngo Y, Rudler M, van der Werf S, Marot S, Thabut D, Sokol H, Housset C, Combes A, Le Grand R, Cacoub P. Maisonnasse P, et al. Gastro Hep Adv. 2022;1(3):393-402. doi: 10.1016/j.gastha.2021.12.009. Epub 2022 Feb 7. Gastro Hep Adv. 2022. PMID: 35174366 Free PMC article.
RESULTS: The area under the receiver operating characteristic curve for A1HPV6 was 0.99 (95% CI 0.97-0.99) in the validation subset, which was not significantly different from that in the construction subset, 0.99 (0.99-0.99; P = .80), like for sensitivity 92% (85-96) vs 9 …
RESULTS: The area under the receiver operating characteristic curve for A1HPV6 was 0.99 (95% CI 0.97-0.99) in the validation subset, which w …