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Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.
Valdes AM, Ravipati S, Pousinis P, Menni C, Mangino M, Abhishek A, Chapman V, Barrett DA, Doherty M. Valdes AM, et al. Among authors: pousinis p. J Lipid Res. 2018 Sep;59(9):1763-1770. doi: 10.1194/jlr.P085118. Epub 2018 Jul 9. J Lipid Res. 2018. PMID: 29986999 Free PMC article.

Of these, 11,12-DHET and 14,15-DHET were higher in affected versus unaffected knees of people with unilateral disease (P < 0.014 and P < 0.003, respectively). Levels of these and 8,9-DHET were also associated with radiographic progression over 3.3 years in 87

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Of these, 11,12-DHET and 14,15-DHET were higher in affected versus unaffected knees of people with unilateral disease (P < 0.014 a

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