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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2003 1
2006 2
2007 4
2008 2
2009 2
2010 1
2013 3
2014 2
2015 1
2016 1
2017 4
2018 2
2019 1
2020 2
2021 1
2022 1
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26 results

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Page 1
Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.
Spégel P, Lindqvist A, Sandberg M, Wierup N. Spégel P, et al. Regul Pept. 2014 Feb 10;189:11-6. doi: 10.1016/j.regpep.2013.12.009. Epub 2014 Jan 8. Regul Pept. 2014. PMID: 24412429
We found that, despite a decrease in serum glucose levels (-26%, p<0.01), the serum metabolite profile was largely unaffected by GIP infusion in normoglycemic rats. Interestingly, levels of branched chain amino acids and the ketone body beta-hydroxybutyrate were decreas …
We found that, despite a decrease in serum glucose levels (-26%, p<0.01), the serum metabolite profile was largely unaffected by G …
Metabolite profiling of obese individuals before and after a one year weight loss program.
Geidenstam N, Al-Majdoub M, Ekman M, Spégel P, Ridderstråle M. Geidenstam N, et al. Among authors: spegel p. Int J Obes (Lond). 2017 Sep;41(9):1369-1378. doi: 10.1038/ijo.2017.124. Epub 2017 May 22. Int J Obes (Lond). 2017. PMID: 28529327
Lower baseline levels of xylitol was predictive of a greater decrease in BMI (beta=0.06, P<0.01) and 10% weight loss (odds ratio (OR)=0.2, confidence interval (CI)=0.07-0.7, P=0.01). Decreases in levels of isoleucine, leucine, valine and tyrosine were associated …
Lower baseline levels of xylitol was predictive of a greater decrease in BMI (beta=0.06, P<0.01) and 10% weight loss (odds ratio ( …
Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial.
Safai N, Suvitaival T, Ali A, Spégel P, Al-Majdoub M, Carstensen B, Vestergaard H, Ridderstråle M; CIMT Trial Group. Safai N, et al. Among authors: spegel p. Diabet Med. 2018 Jul;35(7):944-953. doi: 10.1111/dme.13636. Epub 2018 May 2. Diabet Med. 2018. PMID: 29633349 Clinical Trial.
At baseline, participants on metformin treatment with the highest levels of carnitine C10:1 and leucine/isoleucine had the lowest HbA(1c) (P-interaction = 0.02 and 0.03, respectively). This association was not significant with HbA(1c) at follow-up. ...
At baseline, participants on metformin treatment with the highest levels of carnitine C10:1 and leucine/isoleucine had the lowest HbA(1c) ( …
Treatment of Swedish Patients with Graves' Hyperthyroidism Is Associated with Changes in Acylcarnitine Levels.
Al-Majdoub M, Lantz M, Spégel P. Al-Majdoub M, et al. Among authors: spegel p. Thyroid. 2017 Sep;27(9):1109-1117. doi: 10.1089/thy.2017.0218. Epub 2017 Aug 18. Thyroid. 2017. PMID: 28699427 Clinical Trial.
This was paralleled by altered levels of 9/19 detected acylcarnitines (p < 0.05 after adjustment for multiple testing). Levels of short-chain acylcarnitines were decreased, intermediate-chain acylcarnitines elevated, and long-chain acylcarnitines unaltered. ...

This was paralleled by altered levels of 9/19 detected acylcarnitines (p < 0.05 after adjustment for multiple testing). Levels of

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Metabolite profiling paradoxically reveals favorable levels of lipids, markers of oxidative stress and unsaturated fatty acids in a diabetes susceptible group of Middle Eastern immigrants.
Al-Majdoub M, Spégel P, Bennet L. Al-Majdoub M, et al. Among authors: spegel p. Acta Diabetol. 2020 May;57(5):597-603. doi: 10.1007/s00592-019-01464-w. Epub 2019 Dec 20. Acta Diabetol. 2020. PMID: 31863321 Free PMC article.
RESULTS: The Iraqi immigrant population were more obese (44.1 vs 24.7%, p < 0.05), but had a lower prevalence of hypertension (32.3 vs 54.8%, p < 0.01) than the native Swedish population. ...

RESULTS: The Iraqi immigrant population were more obese (44.1 vs 24.7%, p < 0.05), but had a lower prevalence of hypertension (32.

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Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.
Spégel P, Sharoyko VV, Goehring I, Danielsson AP, Malmgren S, Nagorny CL, Andersson LE, Koeck T, Sharp GW, Straub SG, Wollheim CB, Mulder H. Spégel P, et al. Biochem J. 2013 Mar 15;450(3):595-605. doi: 10.1042/BJ20121349. Biochem J. 2013. PMID: 23282133
This was fulfilled by the NADPH/NADP+ ratio, which was elevated (8-fold; P<0.01) at 6 min after glucose stimulation. The NADPH/NADP+ ratio paralleled an increase in ribose 5-phosphate (>2.5-fold; P<0.001). ...
This was fulfilled by the NADPH/NADP+ ratio, which was elevated (8-fold; P<0.01) at 6 min after glucose stimulation. The NADPH/NAD …
Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans.
Lindqvist A, Spégel P, Ekelund M, Mulder H, Groop L, Hedenbro J, Wierup N. Lindqvist A, et al. Among authors: spegel p. J Clin Endocrinol Metab. 2013 May;98(5):E856-61. doi: 10.1210/jc.2012-3996. Epub 2013 Apr 30. J Clin Endocrinol Metab. 2013. PMID: 23633201 Clinical Trial.

RESULTS: The oral MMT yielded 4.6-fold increase in plasma insulin (P < .05), 2-fold in glucagon-like peptide-1 (P < .05), and 2.5-fold in glucose-dependent insulinotropic peptide (P < .05) plasma levels, compared with the gastrostomy MMT. The changes

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RESULTS: The oral MMT yielded 4.6-fold increase in plasma insulin (P < .05), 2-fold in glucagon-like peptide-1 (P < .05)

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26 results